血清红细胞生成素水平在缺铁性贫血中的临床意义  

Clinical Significance of the Serum EPO Level in Patients with Iron Deficiency Anemia

作　　者：薛春娥[1] 沈庆慧 王艳[1] 张敬宇[1] 林凤茹[1] 

机构地区：[1]河北医科大学第二医院血液科,河北石家庄050000

出　　处：《中国实验血液学杂志》2015年第5期1410-1414,共5页Journal of Experimental Hematology

摘　　要：目的:了解血清红细胞生成素(EPO)水平在缺铁性贫血患者治疗前后的变化及其临床意义。方法:采用酶化学发光法和电化学发光免疫分析法(ECLIA)分别检测37例初诊缺铁性贫血患者治疗前及治疗1个月、2个月和3个月血清EPO的水平及铁蛋白的含量。以30例健康体检者作为正常对照。结果:1缺铁性贫血患者治疗前组、治疗1个月组及治疗2个月组血清EPO水平均高于正常对照组(P<0.05),治疗后各组的sEPO水平均低于治疗前组,随着贫血情况的纠正血清EPO水平逐渐降低,而治疗3个月组与正常对照组sEPO水平差异无统计学意义(P>0.05);缺铁性贫血患者治疗前后的铁蛋白含量均较正常对照组降低(P<0.05),治疗后各组的血清铁蛋白含量均较治疗前组增高,而治疗后各组间血清铁蛋白含量相比差异无统计学意义(P>0.05);2缺铁性贫血患者治疗前后logEPO与血红蛋白呈显著负相关,而缺铁性贫血患者的血清铁蛋白含量,仅在治疗前与血红蛋白含量呈正相关(r=0.449,P=0.005),治疗后各组及正常对照组的铁蛋白含量与血红蛋白均无相关性;3重度贫血组的血清EPO水平明显高于轻、中度贫血组,随着贫血的加重血清EPO水平逐渐升高。结论:EPO参与了红系造血过程,能反映贫血程度,其对贫血的敏感性高于血清铁蛋白,对缺铁性贫血患者评估病情、观察疗效、判断预后均有重要的临床价值。Objective : To investigate the expression level of erythropoietin( EPO) and ferritin before and after treatment of patients with iron deficiency anemia( IDA) so as to explore their clinical significance in diagnosis and discrimination. Methods: The EPO and ferritin levels in serum of 37 patients with IDA were determined by using chemiluminescence analysis( CLIA method) and electrical chemiluminescence analysis( ECLIA method),30 healthy people were randomly selected as normal controls. Results:( 1) the sEPO level in IDA patients of group befor theatment,group treated for 1 month and group treated for 2 months was higher than that in normal control group( P <0. 05). The level of sEPO of IDA patients in different groups after trealment was lower than that in IDA patients of groups before treatment,along with inprovement of anemia status,the level of EPO was gradually reduced,and the level of sEPO in patients of group treated for 3 months was not statistical significant in comparison with that in normal control( P > 0. 05). The level of ferritin in IDA patients before and after treatment was lower than that in normal control group( P < 0. 05). The level of ferritin in IDA patient of groups after treatment was all higher than that in patients of groups before treatment,but comparision of serum ferritin level in patients of groups after treatment did not show statistical significance.( 2) The level of logEPO in IDA patient before and after treatment was negatively related with level of Hb,but the level of ferritin in IDA patients was possitively related with the level of Hb before treatment( r = 0. 449,P =0. 005),the level of ferritin in patients of different group after treatment and in normal group did not related with level of HB.( 3) The level of serum EPO in patients of severe anemia group was obviously higher than that in patients of moderate and mild anemia groups,and along with aggravation of anemia,the EPO level was gradually arised.Conclusion: The serum EPO is involved in the process of erythrocyte hematopoie

关 键 词：缺铁性贫血 促红细胞生成素 铁蛋白 诊断 疗效评估 

分 类 号：R556.3[医药卫生—血液循环系统疾病]