具有造血能力的肌源性干细胞的研究进展  

Research Progress on Muscle-derived Stem Cells Capable of Hematopoiesis ——Review

作　　者：陈玉芳[1] 王媛媛[1] 王娟娟[1] 高晓宁[1] 王晓玲 赵舒武 汪涛 窦昊颖[1] 

机构地区：[1]天津中医药大学护理学院,天津300193 [2]天津中医药大学中西医结合学院,天津300193

出　　处：《中国实验血液学杂志》2015年第5期1523-1526,共4页Journal of Experimental Hematology

基　　金：国家自然科学基金面上项目(81273892);天津市中医药管理局中医;中西医结合基金项目(11030)

摘　　要：肌源性干细胞(muscle-derived stem cells,MDSC)是具有多胚层分化潜能和自我更新能力的成体干细胞群,在造血微环境的诱导下可分化为造血细胞,其造血能力是骨髓造血干细胞的10-14倍,有望成为替代造血干细胞治疗某些骨髓疾患或肿瘤的备选干细胞之一,但在造血微环境下MDSC向造血细胞转化的机制还不十分清晰。MDSC与造血干细胞在生物学特性、蛋白表达和细胞增殖方面有明显差别。此外,MDSC中存在不同分化潜能的干细胞群,但其中具有造血分化潜能较少,而且与造血干细胞起源是否相同还有待进一步研究。本文主要就MDSC中有造血分化潜能的细胞群的分子表型、MDSC与造血干细胞区别、MDSC的起源及其应用前景做一综述。Muscle-derived stem cells( MDSC) are defined as myogenic stem cells endowed with their ability to selfrenew and differentiate into multiple cell types of their derivative tissue,and are proved to be over 10 times more efficient in hematopoiesis than hematopoietic stem cells( HSC). Although the mechanism which MDSC differentiate into blood cells is still unclear,MDSC were considered to replace HSC to treat the patients suffering from bone marrow diseases such as aplastic anemia and tumor. MDSC are different from HSC in a variety aspects like biological characteristics,protein expression and cell proliferation. On the other hand,MDSC contain multiple distinct stem cell populations. Among these,there is only a small part with the ability to repopulate hematopoietic cells,and it is still uncertain whether their origin is same as HSC. This review summarizes the difference between MDSC and HSC,the ability of MDSC to repopulate hematopoietic cells,and the prospect of MDSCs' transplantation.

关 键 词：肌源性干细胞 造血干细胞 造血 体外分化 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]