真核DNA复制起始点的结构与功能研究进展  

Research Progress of Structure and Function on Eukaryotic Origins of DNA Replication

作　　者：张迪[1] 霍克克[2] 

机构地区：[1]中国科学院遗传和发育生物学研究所,北京100080 [2]复旦大学生命科学学院遗传工程国家重点实验室,上海200433

出　　处：《高技术通讯》2003年第12期98-102,共5页Chinese High Technology Letters

基　　金：973 ( 2 10 0CB5 10 2 0 3 );863计划 ( 2 0 0 2AA2 2 70 11)资助项目

摘　　要：DNA复制是细胞分裂的中心环节之一 ,在细胞周期中受到严谨的调控。染色体DNA的复制是由许多复制起点处形成的起始复制叉开始的。复制原点的结构和功能是控制染色体复制的关键因素。在DNA复制起始与RNA转录启动这两种不同的基因表达关键过程之间存在着共有顺式作用序列和共用反式作用因子。对DNA复制的研究是分子生物学的一项基本内容 ,具有重要的理论意义。本文主要对涉及DNA复制起始的顺式元件的结构和功能及其与RNA转录的关系进行了评述和总结。DNA replication is one of the crucial steps to normal cell division. This process is regulated elaborately. Chromosomal DNA replication starts at the sites called Origins by forming replication forks. The structure and function of Origins are key elements to control DNA duplication. There are many common elements including cis-acting DNA elements and trans-acting proteins between Origins of DNA replication and RNA transcription. Both of them are required for gene expression. The study on DNA replication is a basic field in molecular biology, and is valuable for theory development. In this review, we summarized the progress of the structure and function of cis-acting DNA elements in DNA replication and their relationship with RNA transcription.

关 键 词：真核DNA复制 细胞分裂 细胞周期 染色体 RNA 基因表达 分子生物学 

分 类 号：Q343[生物学—遗传学]