氟罗沙星溶液光降解反应机理的探讨  

Study on photodegradation mechanism of Fleroxacin solution

作　　者：饶春意[1] 

机构地区：[1]广东省药品检验所,广州510180

出　　处：《中国药品标准》2003年第6期39-41,共3页Drug Standards of China

摘　　要：目的:研究氟罗沙星溶液光降解反应机理。方法:通过过氧化氢和咪唑对氟罗沙星溶液光降解影响的试验和咪唑对培氟沙星溶液光降解的影响的试验,推断氟罗沙星溶液降解的可能机理。结果:过氧化氢对氟罗沙星光降解有促进作用,咪唑对氟罗沙星和培氟沙星光降解有抑制作用。结论:推断氟罗沙星的光降解反应明显有自由基的参与;而C_8-位的氟取代基是喹诺酮类药物光降解反应中自由基反应的关键基团。Objective: To study the photodegradation mechanism of Fleroxacin solution. Methods: Speculate the photodegra-dation mechanism by studing the influrence of H2O2 and Imidazole to Fleroxacin and investigating the influrence of Imidazole to Pefloxacin. Results:H2O2 can promote the photodegradation of Fleroxacin,Imidazole can restrain the photodegradation of Fleroxacin and Pefloxacin. Conclusions : Free radical is apparently participated in the photodegradation of Fleroxacin ;C8-F is key to the photodegradation of Qumolones.

关 键 词：氟罗沙星溶液 光降解反应 反应机理 过氧化氢 咪唑 

分 类 号：R978.19[医药卫生—药品]