甲氟哌酸药代动力学研究  

Pharmacokinetic Study of Pefloxacin

作　　者：毛伟光[1] 娄建石[2] 王培福[1] 胡文芝[1] 李立津[1] 官兰[1] 

机构地区：[1]天津医学院二附院传染病研究室,300211 [2]天津医学院药理教研室

出　　处：《天津医药》1992年第6期353-355,共3页Tianjin Medical Journal

摘　　要：本文报道国产甲氟哌酸片剂的人体药代动力学研究结果。血、尿药物浓度用微生物打孔法测定。健康志愿者口服甲氟哌酸400mg片剂后,体内药物转运过程符合一室开放模型。甲氟哌酸的血药浓度达峰时间、峰浓度为1.27小时和4.76μg/ml。T_(1/2)Ka和T_(1/2)Ke分别为0.22和10.40小时。研究结果表明,甲氟哌酸吸收快,达峰迅速,血清峰浓度有所提高,消除半衰期长,体内分布广泛,值得在临床推广使用。Clinical pharmacokinetic study of pefloxacin was carried on. The drug concentra-tion was measured by bioassay method. Ten normal volunteers were given a singledose of 400mg of the drug by p.o. adminstration. The serum drug level-time profileof pefloxacin was conformed to the one compartment open model. After oral admini-stration of 400mg pefloxacin, T (Peak), C (max), T1/2ka, T1/2ke were 1.27h, 4.76μg/ml,0.22 and 10.40 hour, respectively. The result indicated that pefloxacin might proveuseful in the treatment of various infections in human beings.

关 键 词：甲氟哌酸 药代动力学 微生物法 人 

分 类 号：R969.1[医药卫生—药理学]