400例急性腹泻病原菌分析及志贺氏痢疾杆菌耐药谱变化  

Pathogen Analysis in Acute Diarrhea in 400 Cases and Changes of Shigella-resistant Spectrum

作　　者：魏殿军[1] 王培福[1] 毛伟光[1] 刘德孟[1] 祁伟[1] 胡文芝[1] 

机构地区：[1]天津医学院第二附属医院传染病研究室,300211

出　　处：《天津医药》1992年第6期329-332,共4页Tianjin Medical Journal

摘　　要：于1990年7月～10月间,从400例急性腹泻患者粪便中共检出致病菌158株。志贺氏菌感染73例占18.25％,仍为腹泻的第一位病原,弧菌科细菌感染48例占12％,其中副溶血弧菌感染15例占3.75％,余为其他病原。34株1990年分离的41株志贺氏菌MIC及MBC测定结果显示,三代喹喏酮类抗生素体外抗菌活性极高,可作为治疗志贺氏痢疾的首选药物。而吡哌酸、庆大霉素的耐药率显著高于往年(P<0.01)From July-Oct, 1990, 400 patients with acute diarrhea were investigated. Therewere 158 strains of pathogenic bacteria isolated from the patients. Shigella speciesremained the most common cause of acute diarrhea in Tianjin (73 strains, 18.25%).The second was vibrio species (48 strains, 12%). The morbidity of shigelloses in thegroup of 7～15 years of age was larger than in the other groups, but in vibrios groupadults had a higher rate. The result of MIC in 34 strains of shigella in 1990 and 41strains in 1984～1986 exhibited that these strains were highly sensitive to new fluoro-quinolone and also sensitive to Ampicillin in vitro. But the rate of resistance to PPAand to Gentamycin was higher than that in 1981～1982 (P<0.01).

关 键 词：腹泻 病因 耐药变迁 志贺氏菌 

分 类 号：R516.03[医药卫生—内科学]