儿童支气管哮喘淋巴细胞亚群以及体液免疫变化规律的初步探讨  

Preliminary Evaluation of Lymphocyte Subpopulations and Humoroimmunal Changes in Pediatric Bronchoasthma

作　　者：王淑芬[1] 阮大宝[1] 陈佩玲[1] 杜怀明[1] 田俊华[1] 钟述猷[2] 刘政[2] 符磊[2] 

机构地区：[1]天津医学院附属医院儿科,300052 [2]天津医学院附属医院免疫实验中心,300052

出　　处：《天津医药》1992年第7期405-408,共4页Tianjin Medical Journal

摘　　要：对100例哮喘患儿进行淋巴细胞亚群及体液免疫功能检测。结果表明:哮喘发作组与正常对照组比较CD_3^+及CD_8^+明显下降;CD_4^+、CD_(20)^+及CD_4^+/CD_8^+比值明显上升,IgE明显上升,IgG明显下降。缓解组细胞及体液免疫各指标均随病情好转趋向正常范围。脱敏治疗前与对照组比较各指标变化与哮喘发作组相近。脱敏治疗后CD_3^+、CD_4^+、CD_8^+及CD_4^+/CD_8^+比值均与对照组无统计学差异。The percentage of lymphocyte subpopulations bearing CD_3^+, CD_4^+, CD_8^+, CD_(20)^+phenotypic markers and the humoral immunity were determined in 100 children with asthma. It was found that the percentage of CD_3^+, CD_8^+ cells and the IgG level dec-reased significantly in patients with asthma, while the percentage of CD_4^+, CD_(20)^+, theCD_4^+/CD_8^+ ratio and the IgE level increased significantly as compared to the normalcontrol. With the improvement of the illness, their cellular immune response and thehumoral immunity tended to resume normal levels. Before deallergization, the cellu-lar and humoral immunity were similar to the asthmatic group, however, after dea-llergization, the CD_3^+, CD_4^+, CD_8^+ and CD_4^+/CD_8^+ ratios turn to become normal with-out any significant statistic differences.

关 键 词：哮喘 淋巴细胞亚群 免疫球蛋白 

分 类 号：R725.6[医药卫生—儿科]