Preparation of β-methyl p-iodophenyl pentadecanoicacid (BMIPP) and ^(125)I-BMIPP  

作　　者：WU Chun-Ying, JI Shu-Ren, LU Chun-Xiong (National Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063) 

出　　处：《Nuclear Science and Techniques》2000年第4期240-246,共7页核技术（英文）

基　　金：Supported by Natural Science Foundation of Jiangsu Province (BK97185)

摘　　要：A method with several steps superior to literature has been developed for the preparation of B-methyl p-iodophenyl pentadecanoic acid(BMIPP). The synthesis and physical properties of BMIPP are described. It is characterized by IR, 1HNMR, elemental analysis and MS. 125I-BMIPP can be prepared by three methods: direct labeling, solid-state transfer labeling and Cu(I ) assisted labeling. Cu(I) assisted labeling is simple and not necessary to purify before clinical use. It can fulfil the requirements for kit labeling.A method with several steps superior to literature has been developed for the preparation of B-methyl p-iodophenyl pentadecanoic acid(BMIPP). The synthesis and physical properties of BMIPP are described. It is characterized by IR, 1HNMR, elemental analysis and MS. 125I-BMIPP can be prepared by three methods: direct labeling, solid-state transfer labeling and Cu(I ) assisted labeling. Cu(I) assisted labeling is simple and not necessary to purify before clinical use. It can fulfil the requirements for kit labeling.

关 键 词：^125I-BMIPP 放射性碘标记 放射性药物 β-甲基P-碘代苯十五烷酸 脂肪酸 

分 类 号：R817.9[医药卫生—影像医学与核医学]