Measurement of ^(153)Sm-EDTMP bone uptake bywhole-body scintigraphy and its application toindividualized treatment dosimetry of bone metastasis  

作　　者：LI Lin, DENG Hou-Fu, LIANG Zheng-Lu, LI Yun-Chun, KUANG An-Ren, TAN Tian-Zhi (The First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041) LUO Shun-Zhong (Southwest Institute of Nuclear Physics and Chemistry, Chengdu 610003) 

出　　处：《Nuclear Science and Techniques》2000年第4期257-262,共6页核技术（英文）

基　　金：Supported by the National Natural Science Foundation of China (No.29971027)

摘　　要：To calculate a safe and effective 153Sm-EDTMP therapy dose, a whole-body scintigraphy technique for prospective individual dosimetry was developed and the results were compared with 5h urine collection method in 20 patients with bone metastases. Anterior and posterior whole-body images were obtained 10 min and 5 h after intravenous injection of 740 MBq 153Sm-EDTMP and the bone uptake value was determined. There is a close correlation between the bone uptake value obtained from the whole-body scintigraphy and 5 h urine collection method (r=0.93). The radiation absorption dose to red marrow was limited to 1.4 Gy and the administered activity calculated from bone uptake value by whole-body scintigraphy was 1.40-2.27GBq (mean 1.90 GBq). If the activity was calculated according to the standard body weight of 37 MBq.kg-1, the administered activity would be 1.75-2.41 GBq (mean 2.18), the radiation absorption dose to red marrow would be 1.37-2.27 Gy (mean 1.63 Gy), but at these doses significant myelotoxicity would be anticipated, thus emphasizing the need for individual prospective dosimetry.To calculate a safe and effective 153Sm-EDTMP therapy dose, a whole-body scintigraphy technique for prospective individual dosimetry was developed and the results were compared with 5h urine collection method in 20 patients with bone metastases. Anterior and posterior whole-body images were obtained 10 min and 5 h after intravenous injection of 740 MBq 153Sm-EDTMP and the bone uptake value was determined. There is a close correlation between the bone uptake value obtained from the whole-body scintigraphy and 5 h urine collection method (r=0.93). The radiation absorption dose to red marrow was limited to 1.4 Gy and the administered activity calculated from bone uptake value by whole-body scintigraphy was 1.40-2.27GBq (mean 1.90 GBq). If the activity was calculated according to the standard body weight of 37 MBq.kg-1, the administered activity would be 1.75-2.41 GBq (mean 2.18), the radiation absorption dose to red marrow would be 1.37-2.27 Gy (mean 1.63 Gy), but at these doses significant myelotoxicity would be anticipated, thus emphasizing the need for individual prospective dosimetry.

关 键 词：^153SM-EDTMP 放射剂量 钐153 全身闪烁扫描法 放射性核素标记 骨移位 诊断 

分 类 号：R817.4[医药卫生—影像医学与核医学]