Effects of valsartan with or without benazepril on blood pressure,angiotensin Ⅱ,and endoxin in patients with essential hypertension  

作　　者：KEYong-Sheng TAOYue-Yu 等 

机构地区：[1]DepartmentofCardiology,YijishanHospital.WannanMedicalCollege,Wuhu241001 [2]DepartmentofCardiology,NanjingNavy414Hospital,SecondMilitaryMedicalUniversity,Nanjing210029,China

出　　处：《Acta Pharmacologica Sinica》2003年第4期337-341,共5页中国药理学报（英文版）

摘　　要：AIM：To eveluate the effects of valsartan(Val)with or without benazepril(Ben)on blood pressure and plasma levels of angiotensin(Ang Ⅱ)and digoxin-immunoreactive factors(endoxin)in patients with essential hypertension. METHODS:Ninety patients with essential hypertension were randomly divided into 3 groups(n=30 per group):Ben group(Ben 10 mg/d,po);Val group(Val 80mg/d,po);combination drug therapy group(Val 80mg/d+Ben 10mg/d,po);all patients were treated for 12 weeks.Age and sex-matched 20 normal subjects were served as control group.RESULTS:The levels of plasma endoxin and ang Ⅱ in patients with essential hypertension were remarkably higher than those in normal subjects.The levels of plasma ang Ⅱ and endoxin were all obvious positive correlation with systolic blood pressure(SBP)and diastolic blood pressure(DBP)(Ang Ⅱ:r=0.5151,0.7978;endoxin:r= 0.4706,0.7274,respectively),within 6 weeks of drug intervene,SBP and DBP were remarkably decreased in 3 groups.After 6 weeks,SBP and DBP were continuously decreased in Ben group and Val+Ben group,but not in Val group.Level of plasma AngⅡ was remarkably decreased as SBP and DBP decreased in Ben group and Val+Ben group;level of plasma AngⅡ was remarkably increased in Val group.CONCLUSION:Val with or without Ben remarkably decreased SBP and DBP in patients with essential hypertension within 6 weeks.Antihypertensive efficacy was weakened after long-term use of Val alone.The antihypertensive effect of Val+Ben group was the most remarkable among 3 groups and could avoid the side effects of high plasma AngⅡ.

关 键 词：原发性高血压 缬沙坦 苯那普利 单用 联合用药 血压 血管紧张素Ⅱ 地高 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]