种植体周骨缺损修复的研究  

A radiographic evaluation or the bone regeneration after repair the peri-implant bone defect

作　　者：陈建钢[1] 张伟[1] 方伟[1] 张俊[2] 赵怡芳[2] 

机构地区：[1]武汉大学中南医院,430071 [2]武汉大学口腔医学院

出　　处：《中华实验外科杂志》2003年第12期1137-1139,共3页Chinese Journal of Experimental Surgery

摘　　要：目的 比较脱钙冻干骨(DFDB)、脱钙冻干骨复合人重组骨形成蛋白-2(rhBMP-2)、脱钙冻干骨联合钛膜的骨修复能力。方法 3条犬股骨种植体周形成 4 mm×3 mm×3 mm的骨缺损,分别植入上述3种不同材料。术后4、8、12周分期处死动物,取含种植体的骨段进行影象学研究。结果 DFDB可单独用于修复种植体周骨缺损,但成骨作用较慢;DFDB+rhBMP-2能较早诱导新骨形成,加速骨整合过程;DFDB+钛膜成骨作用晚于 DFDB+rhBMP-2,但成骨作用较持久、成骨量大、骨密度高。结论 DFDB是一种较理想的骨修复材料,复合rhBMP-2或与钛膜联用时效果更佳。Objective To compare the bone regeneration after repair of the peri-implant bone de- fect using demineralized freeze-dried bone(DFDB), demineralized freeze-dried bone and recombinant hu- man bone morphogentic protein-2 (rhBMP-2), demineralized freeze-dried bone and titanium membrane. Metheds Peri-implant bone defects were created in the thigh of 3 dogs, then treated with above three materials. Animals were sacrified at 4, 8, 12 weeks of postoperation. The specimens were assessed by com- puter-assisted densitometric image analysis. Results Bone regeneration in DFDB group accurred late; DFDB + rhBMP-2 induced early bone regeneration, accelerated the osseointegration; Bone regeneration in DFDB + titanium membrane group was later than DFDB + rhBMP-2, but the bone quantity was larger, density was higher. Conclusion DFDB is a rather ideal bone replacement graft for peri-implant bone de- fect, especially in conjunction with rhBMP-2 and titanium membrane.

关 键 词：种植体 骨缺损 修复 脱钙冻干骨 人重组骨形成蛋白-2 钛膜 

分 类 号：R687[医药卫生—骨科学]