α-内收蛋白、ACE基因多态性及环境因素与高血压病的关系  

Polymorphism of Alpha-adducin, Angiotensin-converting Enzyme(ACE) Genes,Environmental Factors and Essential Hypertension

作　　者：蒋素华[1] 李新立[1] 张海锋[1] 王震震[1] 德伟[2] 袁栎[2] 黄峻[1] 

机构地区：[1]南京医科大学第一附属医院心内科 [2]南京医科大学生化系,江苏南京210029

出　　处：《高血压杂志》2003年第6期563-566,共4页Chinese Journal of Hypertension

基　　金：江苏省自然科学基金项目 (BK2 0 0 2 0 2 9)

摘　　要：目的　研究α -内收蛋白基因、血管紧张素转换酶 (ACE)基因多态性及环境因素与原发性高血压病 (EH)的关系。方法　聚合酶链反应 (PCR) -琼脂糖凝胶电泳检测基因型。结果　 (1)α -内收蛋白基因、ACE基因各基因型及TrpTrp +DD联合基因型在正常血压组和EH组的分布差异无显著性。 (2 )在与EH有关的危险因素存在的条件下 ,肥胖组、高甘油三酯血症组、吸烟组α -内收蛋白基因TrpTrp型EH患者患病率高于其他基因型 ,有统计学差异 (P <0 0 5)。结论　EH是环境与遗传因素共同作用的结果 。Objectives To investigate the relationship between polymorp hism of alpha-adducin and angiotensin-converting enzyme genes and environmental factors and essential hypertension(EH). Methods Genotypes of alpha-adducin gene and AC E genes were determined by polymerase chain reaction (PCR)-agarose gel electrophoresis. Results (1)There were no statistical significance of polymorphism of alpha-adducin gene, ACE gene or TrpTrp+DD combined genotype between hypertensives and healthy subjects. (2)In the presence of the risk factors such as overweight, hyperlipidemia and smoking, the incidence of TrpTrp genotype of alpha-adducin gene in hypertensives is greater than other genotypes. Conclusion It is suggested that environmental factors and genetic traits are interacted in the etiology of EH. Environmental factors might be more important than genetic traits in the pathogenesis of essential hypertension.

关 键 词：高血压 Α-内收蛋白 血管紧张素转换酶 基因多态性 环境因素 聚合酶链反应 琼脂糖凝胶电泳 

分 类 号：R544.1[医药卫生—心血管疾病]