降钙素基因相关肽对血管升压素缩血管效应的影响  

The effect of calcitonin gene-related peptide on vasoconstriction induced by arginine vasopressin

作　　者：叶季鲜 李红梅 黄静 赵连友[2] 

机构地区：[1]解放军323医院心内科,陕西西安710054 [2]第四军医大学唐都医院心内科

出　　处：《心脏杂志》2003年第6期493-494,共2页Chinese Heart Journal

摘　　要：目的 :探讨降钙素基因相关肽 (CGRP)对血管升压素 (AVP)缩血管效应的影响。方法 :培养大鼠主动脉血管平滑肌细胞 (VSMC) ,给予 AVP和 CGRP干预 ,检测 VSMC的细胞内游离钙离子浓度 ([Ca2 + ] i)。结果 :AVP增加VSMC的 [Ca2 + ] i,而 CGRP明显抑制 AVP的这一作用。结论 :CGRP可能通过抑制 VSMC的 [Ca2 + ] i的升高而发挥其对AIM:To investigate the effect of calcitonin gene-related pe ptide(CGRP) on the vasoconstriction induced by arginine vasopressin(AVP). METHODS:The aortic vascular smooth muscle cell(VSMC) of rat was cultured to determine the cytosolic free Ca 2+ concentration ([Ca 2+ ] i) in the presence of CGRP and AVP. RESULTS:AVP increased [Ca 2+ ] i,which was signi ficant ly attenuated by CGRP. CONCLUSION:CGRP plays the inhibitory effect on AVP-induced vasoconstriction by confining increased [Ca 2+ ] i of VSMC.

关 键 词：降钙素基因相关肽 血管升压素 血管平滑肌细胞 细胞内游离钙 缩血管效应 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]