野罂粟总生物碱对人淋巴细胞微核的影响  

EFFECTS OF THE TOTAL ALKALOID OF PAPAVER NUDICAULE L. ON THE MICRONUCLEU OF HUMAN LYMPHOCYTES

作　　者：肖桂芝[1] 刘朝晖[1] 龚秀云[1] 王栋[1] 冯立新[1] 卜玲[1] 厚今[1] 

机构地区：[1]承德医学院,河北承德067000

出　　处：《承德医学院学报》2003年第4期291-292,共2页Journal of Chengde Medical University

摘　　要：目的 :探讨野罂粟总生物碱 (TAPN)对人淋巴细胞的毒性效应。方法 :采用细胞培养技术 ,检测TAPN对人淋巴细胞微核的影响。结果 :TAPN 3μg及 5μg组与空白对照组无差异 (P>0 .0 5 ) ,其余各浓度组均能诱导人淋巴细胞微核率升高。结论 :TAPN各浓度组与微核率之间存在着明显的剂量效应 ,但Objective: To explore the poisonous effects of the total alkaloid of Papaver nudicaule L.(TAPN) on human lymphocyte.Methods: Cell culture method is applied to check and measure the micronuclei(MN) rates of human lymphocyte effected by TAPN. Results: No significant difference was present between the groups with administration of 3μg and 5μg TAPN and the control group. Other groups in different concentration of the TAPN can induced the lymphocyte to increase the multiplication rate of MN. Conclusion: The dose and effect relationship existed obviously between MN rates and TAPN in different consistency groups. The conclusion can be drawn from the studies that TAPN does not induce the change of MN rates in common dosage.

关 键 词：野罂粟总生物碱 淋巴细胞 微核 毒性效应 细胞培养 

分 类 号：R285.1[医药卫生—中药学]