诺维本致大鼠组织损伤后处理的实验研究  

Experimental Study of therapy in the tissue damage of rat caused by Vinorelbine

作　　者：戴建华[1] 叶文琴[2] 丁翠琴[3] 刘俊麟[4] 金欢妹[3] 刘玲[3] 罗婷[3] 

机构地区：[1]第二军医大学附属长海医院住院二部,上海市200433 [2]长海医院护理部 [3]长海医院外宾诊疗部 [4]第二军医大学2002年级研究生大队

出　　处：《中华护理杂志》2003年第12期916-918,共3页Chinese Journal of Nursing

基　　金：医院护理部 2 0 0 1年度护理科研资助课题

摘　　要：目的 :运用大鼠模型探讨诺维本致组织损伤后的最佳处理方法。方法 :将 4 8只SD大鼠建立诺维本组织损伤模型后随机分为 4组 ,即对照组、局封加冷敷组、局封加热敷组、透明质酸酶加红外线照射组。于 2 4h、1周、2周分别进行局部组织病理学检查。结果 :透明质酸酶加红外线照射组对诺维本致大鼠组织病理改变有明显减轻作用 ,局封加冷敷组未见明显疗效。结论Objective: The purpose of this study was to determine the most effective therapy to decrease the severity of tissue damage of rat caused by Vinorelbine in a mouse model. Method: After establishing an animal model of Vinorelbine-induced tissue damage in 48 Sprague-Dawley rats, the Sprague-Dawley rats were randomly divided into four groups. Three methods were tested: lidocaine injection plus topical cold, lidocaine injection plus topical heat, hyaluronidase injection plus Infrared radiation,and nothing for the control group. The pathological examination was completed at 24 hours as well as one week and two weeks later.Result:Hyaluronidase injection plus Infrared radiation was significant in decreasing the severity of tissue damage of rat caused by Vinorelbine while the method of lidocaine injection plus topical cold was useless. Conclusion: Hyaluronidase injection plus Infrared radiation is the best means of reducing the Vinorelbine-induced tissue damage.

关 键 词：诺维本 组织损伤 处理 实验研究 红外线 透明质酸葡糖胺酶 

分 类 号：R96[医药卫生—药理学]