静脉用药不良反应与药液中不溶性微粒数量相关性的初步分析  

Analysis of the association between the quantity of insoluble particles in intravenously admin-istered solution with adverse drug reactions

作　　者：汪艳[1] 王桂芳[1] 叶海英[1] 

机构地区：[1]第一军医大学珠江医院药剂科,广东广州510282

出　　处：《第一军医大学学报》2004年第1期24-26,共3页Journal of First Military Medical University

基　　金：广东省医学科研基金(A2003471)~~

摘　　要：目的探讨静脉用药不良反应与有关不溶性微粒数量的相关性。方法模拟临床输液配制操作过程,对本院临床常用药配伍,测定进入病人静脉前液体不溶性微粒的数量。结果经输液器后不溶性微粒的数量均未超过中国药典中规定的相应标准。结论本院绝大部分输液药物不良反应可排除由于中国药典规定的有关微粒数量超标而引起的可能性。Objective To investigate th e possible association between adverse drug reactions and the quantity of insolu ble par-ticles in the intravenously administred drugs. Methods The solutions wer e prepared following the procedures in routine clini-cal practice, and the quant ity of insoluble particles in these solutions were measured before and after the solutions went through the transfusion apparatus. Results The quantity of inso luble particles measured after the solutions passed through the transfu-sion app aratus was consistent with the standard documented in Chinese Pharmacopoeia. Con clusion Adverse intravenous re-actions occurring in our hospital has no associat ion with excessive quantity of insoluble particles in the administered drugs.

关 键 词：静脉用药 药物不良反应 药液 不溶性微粒 相关性 微粒数量 

分 类 号：R453[医药卫生—治疗学]