D-氨基葡糖盐酸盐制备方法的改进  

Improved preparation of D-glucosamine hydrochloride

作　　者：夏士朋[1] 

机构地区：[1]淮阴师范学院化学系,江苏淮安223001

出　　处：《中国医药工业杂志》2004年第1期11-12,共2页Chinese Journal of Pharmaceuticals

摘　　要：改进了D-氨基葡糖盐酸盐的制备,仅用原工艺30％盐酸的半量,革除酸水解液的浓缩,避免了对设备的腐蚀。改进后的最佳工艺条件:甲壳质-30％盐酸(1:3,w/w),水解温度80℃,水解时间2h,洗涤剂为95％乙醇,干燥温度低于60℃。含量为99.5％,收率约70％。The preparation of D-glucosamine hydrochloride was improved. Only half volume of 30% hydrochloric acid was used for hydrolysis of chitin, thus the concentration of the acid hydrolysate was omitted to avoid the corrosion problem. The optimized conditions were as follows: the ratio of chitin to 30% hydrochloric acid was l:3(w/w), hydrolysed at 80 ℃ for 2h, 95% ethanol was used as wash solvent, product dried below 60 ℃. The purity and yield of D-glucosamine hydrochloride were 99.5% and 70%, respectively.

关 键 词：D-氨基葡糖盐酸盐 甲壳质 制备 最佳工艺 

分 类 号：TQ462[化学工程—制药化工] R977.5[医药卫生—药品]