血清瘦素、肿瘤坏死因子-α与慢阻肺疾病患者营养不良的关系研究  

The Investigation of Relations between the Serum Levels of Leptin and TNF-α and Malnutrition in Chronic Obstructive Pulmonary Disease

作　　者：杨红辉[1] 孙圣华[1] 刘纯[1] 刘宗道[1] 刘建明[1] 丘万服[1] 

机构地区：[1]中南大学湘雅三医院呼吸科,湖南长沙410013

出　　处：《中国医师杂志》2004年第1期56-57,共2页Journal of Chinese Physician

摘　　要：目的　研究瘦素 (leptin)、肿瘤坏死因子 -α(TNF -α)对慢性阻塞性肺疾病 (COPD)患者营养状态的影响及其可能机制。方法　用酶联免疫吸附试验 (ELISA)测定 62例COPD患者及 3 0名正常人血清瘦素、肿瘤坏死因子 -α浓度 ,测定各组体重 (BW )、身高 (H) ,计算体重指数 (BMI)、理想体重百分比 (NW %)、肺功能 ,分析瘦素与各项参数的相关性。结果　COPD急性期组血清瘦素、TNF -α水平高于临床缓解期组及正常对照组 ,临床缓解期组血清瘦素低于正常对照组 ,但TNF -α水平高于正常对照组 ,差异均有显著性 (P <0 0 5 )。结论　血清瘦素与COPD患者的营养参数相关 ,血清瘦素、TNFObjective To investigate the effects of serum leptin and tumor necrosis factor-α(TNF-α) on nutrition states in patients with chronic obstructive pulmonary disease (COPD). Methods The serum leptin and TNF-α levels were examined. Body mass index (BMI) and percent age of normal body weight(NW%) were measured. The correlation between leptin and other parameters was analysed. Results Serum leptin and TNF-α levels in acute exacerbation of COPD were significantly higher than those in the stable patients with COPD and control (P<0.05). Serum leptin concentration in stable patients with COPD was lower than that in the control, but the TNF-α level was higher than that in the control. Conclusion The elevated leptin and TNF-α levels may related to the aggravation and the malnutrition in patients with COPD.

关 键 词：血清瘦素 肿瘤坏死因子-Α 营养不良 慢性阻塞性肺疾病 酶联免疫吸附试验 炎症反应 

分 类 号：R563.9[医药卫生—呼吸系统]