短期胰岛素强化治疗初诊2型糖尿病对胰岛β细胞功能影响的观察  

The Effects of Short-term Intensive Insulin Treatment on Pancretic β Cell Function in Newly Diagnosed Type 2 Diabetic Patients

作　　者：李华珠[1] 王敏[1] 刘湘华[1] 周桂莲[1] 

机构地区：[1]湖南省人民医院内分泌科,湖南长沙410002

出　　处：《中国医师杂志》2004年第1期82-83,共2页Journal of Chinese Physician

摘　　要：目的　观察短期胰岛素强化治疗对伴明显高血糖的初诊 2型糖尿病患者的降糖效果和胰岛 β细胞功能的影响。 方法　对 2 7例空腹血糖 >13 1mmol/L的初诊T2 DM患者进行短期胰岛素强化治疗 ,分析比较其治疗前后空腹血糖 (FBS)、糖化血红蛋白(HbA1c)、空腹血胰岛素 (FINS)及餐后 2h血糖 (PBS2 )、胰岛 β细胞功能Homaβ及胰岛素敏感性指标HomaIR的变化。 结果　治疗 2周后 ,2 3例患者的空腹及餐后 2h血糖分别于治疗后 ( 5 6± 2 3 )d、( 8 5± 3 5 )d达到良好控制 ;FBS及PBS2 水平均较治疗前显著下降(P <0 0 1) ;HbA1c、HomaIR较治疗前下降 (P <0 0 5 )、Homaβ较治疗前增高 ( P <0 0 5 )。结论　对伴明显高血糖的初诊 2型糖尿病患者 ,短期胰岛素强化治疗具有快速控制血糖 ,从而明显改善Objective To explore the effect of short-term intensive insulin treatment on pancreatic β-cell function and glycemia control in newly diagnosed type 2 diabetic patients with severe hyperglycemia. Methods Twenty-seven newly diagnosed type 2 diabetic patients with fasting blood sugar (FPG)>13.1mmol/L were treated by 2 weeks short-term intensive insulin treatment. FBS, Fasting blood insulin(FINS), glycosylated hemoglobin A1c (HbA1c), 2 hours postprandial blood sugar(PBS 2), Homa β and Homa IR were measured and compared between pre-treatment and post-treatment. Results After 2 weeks short-term intensive insulin treatment, the excellent control of FBS, PBS 2 in 23 out of 27 patients were achieved respectively in (5.6±2.3)days and (8.5±3.5)days. Homa β significantly increased, and HbA1c and Homa IR decreased comared with pre-treatment. Conclusions The excellent glycemia control and improvement of β-cell function can be induced by short-term intensive insulin treatment in newly diagnosed type 2 diabetic patients with severe hyperglycemia.

关 键 词：胰岛素 2型糖尿病 胰岛Β细胞 血糖 强化治疗 

分 类 号：R587.1[医药卫生—内分泌]