硝苯地平缓释微丸的体外释药机制  

Release Mechanisms of Nifedipine Sustained-release Beads in Vitro

作　　者：马萍[1] 孙淑英[2] 辛艳茹 

机构地区：[1]中国人民解放军第二炮兵总医院,药剂科,北京100088 [2]沈阳药科大学,辽宁沈阳110015 [3]不详

出　　处：《解放军药学学报》2003年第6期424-426,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的　考察自制硝苯地平缓释微丸的体外释药机制。方法　按中国药典 (2 0 0 0版 )浆法 ,进行体外释放度测定 ,累积释放度数据经计算机处理。结果　本文自制硝苯地平缓释微丸为亲水性凝胶骨架制剂 ,体外释放机制包括药物扩散和骨架溶蚀两种作用。结论　自制硝苯地平缓释微丸体外缓释 ,有进一步开发的价值。Aim To inspect the release mechanisms of nifedipine sustained-release beads in vitro.Methods According to the plasm method of Chinese Pharmacopeia (2000),the dissolution was determined and the accumulated dissolution data was processed.Results The nifedipine sustained-release beads was hydrophilic gel frame,drug diffusion and frame erosion was the release mechanisms in vitro.Conclusion The nifedipine sustained-release beads was sustained-release in vitro and was worthy of being deueloped.

关 键 词：硝苯地平 缓释微丸 体外释药机制 药物 血药浓度 

分 类 号：R972[医药卫生—药品]