普伐他汀对内皮依赖性血管舒张功能的影响  

Protective effect of pravastatin on endothelium-dependent vasodilation

作　　者：王立旗[1] 霍本良[1] 翟红兵[1] 王春华[2] 徐用祜[1] 

机构地区：[1]开封市第二人民医院心内科,河南开封475002 [2]开封市第二人民医院超声科,河南开封475002

出　　处：《临床心血管病杂志》2004年第1期24-25,共2页Journal of Clinical Cardiology

摘　　要：目的 :评价普伐他汀对内皮依赖性血管舒张功能的影响。方法 :对 5 8例冠心病 (CHD)患者 (A组 )及 30例健康人 (B组 )采用高分辨血管外超声技术测定肱动脉血流介导的舒张功能及硝酸甘油介导的舒张功能。A组服普伐他汀 6个月后复查。结果 :A组肱动脉血流介导的舒张及硝酸甘油介导的舒张均低于B组 [分别为(2 .85± 2 .77) %∶(8.14± 3.6 5 ) %、(16 .6 8± 5 .71) %∶(2 4 .83± 6 .79) % ,均P <0 .0 1],A组治疗后较治疗前明显好转 [分别为 (6 .4 5± 3.82 ) %∶(2 .85± 2 .77) %、(2 2 .4 6± 6 .37) %∶(16 .6 8± 5 .71) % ,均 P <0 .0 1]。结论 :普伐他汀对CHD患者受损的内皮依赖性舒张功能有较好的治疗价值 。Objective: To evaluate the effect of pravastatin on endothelium-dependent vasodilation. Methods: Fifty-eight patients with coronary heart disease (Group A) and 30 normal subjects (Group B) were studied, the flow-mediated dilatation and glyceryl trinitrate (GTN) -induced vasodilation of brachial artery were detected by high-resolution ultrasound technique. After six-month-treatment with provastatin , subjects in group A were redetected. Results: Both flow-mediated dilatation and GTN-induced vasodilation of brachial artery in group A were reduced compared with group B [( 2.85± 2.77)% vs ( 8.14± 3.65)% and ( 16.68%± 5.71)% vs ( 24.83± 6.79)%,respectively, P< 0.01 for all). In group A, these index were significantly better after treatment with pravastatin than before [( 6.45± 3.82)% vs ( 2.85± 2.77)% and ( 22.46± 6.37)% vs ( 16.68± 5.71)%, respectivey, P< 0.01 for all]. Conclusion: Pravastatin have a good protective effect on endothelium-dependent vasodilation.

关 键 词：普伐他汀 内皮依赖性血管舒张功能 冠心病 测定 肱动脉血流 硝酸甘油 

分 类 号：R541.4[医药卫生—心血管疾病] R972.6[医药卫生—内科学]