N-acetyl cysteine therapy in acute viral hepatitis  

作　　者：Huseyin Gunduz Oguz Karabay Ali Tamer Resat zaras Ali Mert mer Fehmi Tabak 

机构地区：[1]Department of Internal Medicine and Cordiology,Izzet Baysal Medical Faculty,Izzet Baysal University/Bolu,Turkey [2]Department of Infectious Diseases and Clinical Microbiology,Izzet Baysal Medical Faculty,Izzet Baysal University/Bolu,Turkey [3]Department of Internal Medicine,Izzet Baysal Medical Faculty,Izzet Baysal University/Bolu,Turkey [4]Department of Infectious Diseases and Clinical Microbiology,Cerrahpasa Medical Faculty,Istanbul University,Findikzade/lstanbul,Turkey

出　　处：《World Journal of Gastroenterology》2003年第12期2698-2700,共3页世界胃肠病学杂志（英文版）

摘　　要：AIM: To investigate the effect of N-acetyl cysteine (NAC)on acute viral hepatitis (AVH).METHODS: We administered 200 mg oral NAC three times daily (600 mg/day) to the study group and placebo capsules to the control group. All patients were hospitalized and diagnosed as AVH. Blood total and direct bilirubin, ALT, AST,alkaline phosphatese, albumin and globulin levels of each patient were measured twice weekly until total bilirubin level dropped under 2 mg/dl, ALT level under 100 U/L, follow up was continued and then the patients were discharged.RESULTS: A total of 41(13 female and 28 male) AVH patients were included in our study. The period for normalization of ALT and total bilirubin in the study group was 19.7±6.9 days and 13.7±8.5 days respectively. In the control group it was 20.4±6.5 days and 16.9±7.8 days respectively (P＞0.05).CONCLUSION: NAC administration effected neither the time necessary for normalization of ALT and total bilirubin values nor duration of hospitalization, so we could not suggest NAC for the treatment of icteric AVH cases. However, our results have shown that this drug is not harmful to patients with AVH.AIM:To investigate the effect of N-acetyl cysteine (NAC) on acute viral hepatitis (AVH). METHODS:We administered 200 mg oral NAC three times daily (600 mg/day) to the study group and placebo capsules to the control group.All patients were hospitalized and diagnosed as AVH.Blood total and direct bilirubin,ALT,AST, alkaline phosphatese,albumin and globulin levels of each patient were measured twice weekly until total bilirubin level dropped under 2 mg/dl,ALT level under 100 U/L,follow up was continued and then the patients were discharged. RESULTS:A total of 41(13 female and 28 male) AVH patients were included in our study.The period for normalization of ALT and total bilirubin in the study group was 19.7±6.9 days and 13.7±8.5 days respectively.In the control group it was 20.4±6.5 days and 16.9±7.8 days respectively (P>0.05).CONCLUSION: NAC administration effected neither the time necessary for normalization of ALT and total bilirubin values nor duration of hospitalization, so we could not suggest NAC for the treatment of icteric AVH cases. However, our results have shown that this drug is not harmful to patients with AVH.

关 键 词：ACETYLCYSTEINE Acute Disease ADOLESCENT ADULT Alanine Transaminase Antiviral Agents Aspartate Aminotransferases BILIRUBIN Comparative Study FEMALE Hepatitis A Hepatitis B Humans Liver Function Tests MALE Middle Aged Reference Values 

分 类 号：R512.6[医药卫生—内科学]