高血压对糖尿病肾病进展的影响(附51例4年随访报告)  

Influence of Hypertension on Progression of Diabetic Nephropathy:A 4-years' Follow-up of 51 Cases

作　　者：阴东平[1] 张萍萍[1] 周伟君[1] 孙蔚明 

机构地区：[1]南京铁道医学院附院,210009

出　　处：《铁道医学》1992年第3期142-143,共2页Railway Medical Journal

摘　　要：51例糖尿病肾病患者分为高血压组和正常血压组。4年来动态观察其血压、血糖、尿微白蛋白排泄率(AER)、肾功能。发现两组间血糖和糖化血红蛋白相差和变化不大。高血压组AER平均值和4年上升幅度均高于正常血压组(分别为P<0.001,P<0.005)。肾功能以1/cr·t^(-1)表示,两组首次肌酐值近似,4年中肾功损失程度按Mitch方法以斜率b表示,两组间差异显著(P<0.001)。提示高血压是糖尿病肾病进展中的危险因素。Fifty-one patients with diabetic nephropathy were divided into two groups:hypertensive ( HG ) and normotensive ( NG ).Data on sequential changes in blood glucose, microalbuminuria ( μALb ) and renal function were obtained on 4-years' longitudinal study. Fasting biood glucose and glycosylated hemoglobin had no significant change in both groups within follow-up period, whereas μALb in HG had a higher mean value and a higher increase than in MG (P<0.05, P<0.001, respectively ). The slopes of 1/Cr·t^(-1) had a significant difference between 2 groups,b= 0.089 in HG vs b= 0.134 in NG(P<0.001). Thus, hypertension appears to be a major risk factor for accelerating μALb and renal change in DN.

关 键 词：高血压 糖尿病性肾病 血糖 

分 类 号：R587.2[医药卫生—内分泌]