肾脏病患者血浆心钠素水平的初步观察  

Observation of Plasma ANP Levels in Patients with Renal Diseases

作　　者：阮玉琚 张增华[1] 桓文穆[1] 文薇[1] 

机构地区：[1]广州铁路中心医院,510080

出　　处：《铁道医学》1992年第3期146-147,共2页Railway Medical Journal

摘　　要：用放射免疫法测定61例健康人和53例慢性肾脏疾病患者血浆心钠素和血清β2-微球蛋白(β2-M)含量。结果表明慢肾(肾功能代偿期)患者血浆心钠素含量较健康人高(P>0.05);而β2-M较健康人显著增高(P<0.001)。肾功能衰竭患者血浆心钠素与血清β2-M含量均显著增高(P<0.001)。11例肾衰患者血透治疗前后心钠素与电解质均有明显差异。结果提示,心钠素可作为推测肾功能指征之一,但不如β2-M可靠;心钠素功能降低,可能是高血压形成的重要因素之一。Plasma ANP and serum β_2-M levels were determined in 61 healthy people and 53 patients with chronic renal diseases using radioimmunoassay. It showed that the plasma ANP levels in patients were higher than those in healthy people (P>0.05 ) and the β_2-M levels in patients were much higher than those in healthy people (F<0.001 ).Significant disserences in levels of ANP and electrolytes were found in 11 patients with CRF before and after hemodialysis. ANP is suggested to be one of the predictors of renal function, but not reliable as β_2-M.A decreased plasma ANP may be one of the causes of hypertension.

关 键 词：肾功能衰竭 血液透析 心钠素 

分 类 号：R692.502[医药卫生—泌尿科学]