陈皮提取物体内抗肿瘤作用及其对癌细胞增殖周期的影响  

Study on the Anticancer Activities (In Vivo) of the Extract from Citrus reticulata Blanco and Its Influence on Sarcoma-180 Cells Cycle

作　　者：钱士辉[1] 王佾先[2] 亢寿海[2] 杨念云[1] 袁丽红[3] 

机构地区：[1]江苏省中医药研究院中药化学研究室,江苏南京210028 [2]江苏省肿瘤防治研究所,江苏南京210009 [3]南京工业大学,江苏南京210009

出　　处：《中国中药杂志》2003年第12期1167-1170,共4页China Journal of Chinese Materia Medica

基　　金：江苏省科技厅应用基础项目 (BJ990 75 )

摘　　要：目的 :进行陈皮提取物体内抗肿瘤作用的研究。方法 :采用肉瘤 180 (S180 )、肝癌 (Heps)、艾氏腹水癌(EAC)移植性肿瘤模型 ,进行了抑制肿瘤的试验。结果 :陈皮提取物对小鼠移植性肿瘤S180 ,Heps具有明显的抑制作用 ,与空白对照相比 ,具有显著性差异 (P <0 .0 5 ) ;对艾氏腹水癌 (EAC)的延长生命作用无显著性差异 (P >0 .0 5 ) ;对癌细胞增殖周期S期细胞作用不大 ,但能使G2 M细胞减少 ,使G0 G1期细胞增多 ,同时具有促使癌细胞凋亡的作用。结论 :陈皮提取物是一种有开发前景的抗肿瘤中药活性成分。Objective:To study the anticancer activity of the extract from Citrus reticulata in vivo . Method: Anticancer activities were tested with tumor model in vivo (Sarcoma-180 cells,Heps cells,EAC cells implanted in mice). Result: The extract from Citrus reticulata showed marked anticancer activities on Sarcoma-180 cells and Heps cells implanted in mice, had no marked anticancer activities on EAC cells implanted in mice and induced apoptosis of Sarcoma-180 cell. Conclusion: The extract from Citrus reticulata will have promising prospects as an anticancer Chinese medicine, but further studies will be needed.

关 键 词：陈皮提取物 体内 抗肿瘤作用 癌细胞 细胞增殖 细胞周期 小鼠 

分 类 号：R285.5[医药卫生—中药学]