葛根素注射液对急性血瘀模型大鼠血液流变性改善作用的实验研究  

Experimental Study of Puerarin Injection on the Hemorheology in Acute Blood-stasis Model Rats

作　　者：潘洪平[1] 杨嘉珍[1] 李吕力[1] 易菲[1] 黄作群[1] 黄开文[1] 

机构地区：[1]广西壮族自治区人民医院,广西南宁530021

出　　处：《中国中药杂志》2003年第12期1178-1180,共3页China Journal of Chinese Materia Medica

基　　金：广西壮族自治区卫生厅医药卫生科研课题 (合同号 :Z2 0 0 10 72 )

摘　　要：目的 :观察葛根素注射液对急性血瘀模型大鼠血液流变性的影响。方法 :给大鼠皮下注射大剂量盐酸肾上腺素后 ,再施以冰水浸泡制作急性血瘀模型大鼠 ;采用全自动血流变学仪测定不同切变率的全血黏度、血浆黏度、血液屈服应力、红细胞聚集指数和血小板最大聚集率等指标 ;观察葛根素注射液对急性血瘀模型大鼠血液流变学诸指标的影响。结果 :急性血瘀模型大鼠的全血黏度、血浆黏度均明显升高 (与正常对照组比较 ,P <0 .0 1,P <0 .0 5 ) ,血液屈服应力明显增大 (P <0 .0 1)。葛根素注射液高、低剂量组均可明显降低急性血瘀大鼠的全血黏度 ,减小血液屈服应力 (与模型组比较 ,P <0 .0 1,P <0 .0 5 ) ;降低其血小板最大聚集率 (P均 <0 .0 5 ) ;高剂量组还可明显降低红细胞聚集指数和红细胞变形指数 (P <0 .0 5 )。结论 :葛根素注射液有明显改善急性血瘀模型大鼠的血液流变性作用 ,且呈现一定的量效关系。Objective: To observe the effect of Puerarin Injection on the hemorheology in acute blood-stasis model rats. Method: The acute blood-stasis model rats were made by being soaked in ice water afer being injected adrenaline hydrochloride injection in a major dose.The changes of viscosity of whole blood and plasma,blood yield stress, erythrocyte aggregation and the maximum rate of platelet aggregation in the acute blood-stasis model rats were measured with Auto-Viscometer,and then the influence of Puerarin Injection on the hemorheology in the model rats was investigated. Resuit: The viscosity of whole blood and plasma, and blood yield stress in the acute blood-stasis model rats were significantly higher than those in the normal control group( P <0.01, P <0.05).Both the high dose and the low dose of Puerarin Injection could reduce the viscosity of whole blood and plasma, blood yield stress and the maximum rate of platelet aggregation in the acute blood-stasis model rats( P <0.01, P <0.05). The high dose could also reduce the erythrocyte aggregation and the deformed Index of red blood cell( P <0.05). Conclusion: Puerarin Injection can ameliorate the hemorheology in acute blood-stasis model rats,and it has a dose-response relationship.

关 键 词：葛根素注射液 急性血瘀 动物模型 大鼠 血液流变性 实验 

分 类 号：R285.5[医药卫生—中药学]