氨噻肟酸乙酯的生产工艺改进  

Improvement of Process for Producing Ethyl (Z)-2-Methoxyimino-2-(2-aminothiazo-4-yl) Acetate

作　　者：刘静[1] 杨锋[2] 鹿峰[3] 姚庆林[3] 

机构地区：[1]南京工业大学,江苏南京210000 [2]青岛科技大学,山东青岛266042 [3]济南市化工研究所,山东济南250100

出　　处：《青岛科技大学学报（自然科学版）》2003年第5期412-414,共3页Journal of Qingdao University of Science and Technology:Natural Science Edition

摘　　要：以乙酰乙酸乙酯为原料 ,经亚硝化、甲基化、溴化、环合连续反应生产氨噻肟酸乙酯 ,对各步合成工艺进行了改进 ,总收率提高到 70 .8%,简化了操作 。Ethyl Z 2 Methoxyimino 2 (2 aminothiazo 4 yl) acetate was synthesized through nitrosation, methylation, bromination and cyclization by using ethyl acetoacetate as raw material.The synthesis process for each step was improved. Based on the improvement,the operation proceduce was simplified and the production cost was reduced. The product yield was 70.8 %.

关 键 词：氨噻肟酸乙酯 生产工艺改进 乙酰乙酸乙酯 亚硝化 甲基化 溴化 环合 头孢菌素 

分 类 号：TQ463.53[化学工程—制药化工]