赛庚啶对大鼠性腺作用的形态学观察  

Morphological Investigation on the Effect of Cyproheptadine on the Sex Gland of Rat

作　　者：李锋杰[1] 康白[2] 王尊哲[1] 胡庆伟[2] 高尔[2] 

机构地区：[1]潍坊医学院形态学实验室,山东潍坊261042 [2]潍坊医学院应用药理学重点实验室,山东潍坊261042

出　　处：《解剖科学进展》2003年第4期321-322,共2页Progress of Anatomical Sciences

摘　　要：目的　研究赛庚啶 (cyproheptadine,CYP)对大鼠卵巢和睾丸超微结构的影响。方法　用透射电子显微镜观察经 4 6mg/kg/d赛庚啶灌胃后对卵巢和睾丸组织超微结构的改变。 结果　试验组大鼠卵巢中卵泡细胞和黄体细胞线粒体肿胀、嵴断裂 ,出现髓样变 ,甚至呈空泡样 ,卵泡细胞粗面内质网脱颗粒。睾丸组织未见明显改变。结论　赛庚啶对雌性大鼠卵泡细胞和黄体细胞超微结构产生明显影响。Objective To investigate the effect of Cyproheptadine on the ultrastructure of the rat ovary and testis. Methods The change of ultrastructure of ovary and testis after treating orally with 4.6mg/kg/d of cyproheptadin was observed under the transmmission electronic microscope. Results The mitochondria of follicular cells and corpus luteum of female rats were swollen, cristae fractured, and myelonic and vacuolar in the ovary in experimental group. And degranulation also appeared in rough endoplasmic reticulum in follicular cells, while no obvious change was found in testis. Conclusion Cyproheptadine caused the obvious changes of the ultrastructure of the follicular cells and corpus luteum of female rats.

关 键 词：赛庚啶 大鼠 性腺 形态学观察 超微结构 

分 类 号：R335.5[医药卫生—人体生理学]