仿SOD催化剂的合成及其清除氧自由基作用  

The Synthesis of the Catalyst Imitating SOD and Its Functions of Scavenging Oxygen Free Radicals

作　　者：何永言[1] 吴蒙[1] 魏祖期[1] 贾菊芳[2] 李勇军[2] 王海龙[3] 

机构地区：[1]同济医科大学基础医学部化学教研室 [2]济医科大学基础医学部药理学教研室 [3]济医科大学基础医学部华中理工大学化学系

出　　处：《同济医科大学学报》1992年第4期261-264,共4页Acta Universitatis Medicinae Tongji

基　　金：国家自然科学基金

摘　　要：合成了一种钢配合物[Cu_2(C_(34)H_(32)N_(10)(Br)_3)Br·2H_2O作为仿Cu·Zn-SOD催化剂,用核黄素-蛋氨酸光照法等证实它有清除的作用;ESR等证实它还有清除,OH的作用;大鼠心脏缺血再灌注实验表明此铜配合物能降低活性氧自由基(和·OH)对心肌的损伤程度,对再灌注损伤心肌有保护作用。The Cu(I) coordination compound [Cu2(C34H32N10)(Br)3]Br· 2H2O as a novel catalyst imitating Cu.Zn-SOD has been synthesized. It has two functions. Its first function, scavenging of O2- has been proved by using the Riboflavin-Methionine photoreduction method and other means, while its second one, scavenging of ·OH,has been confirmed by ESR spectrum and other assays. The experimental results of ischemia-reperfusion of myocardium in rats show that this compound can reduce the reperfusion-induced damage caused by active oxygen free radicals.

关 键 词：自由基去除剂 催化剂 超氧物歧化酶 

分 类 号：R969[医药卫生—药理学]