^(99)Tc^m-GH与ECD之间的配体交换反应动力学研究  

A KINETIC STUDY ON LIGAND EXCHANGE REACTION BETWEEN ^(99)Tc^m-GH AND ECD

作　　者：方平[1] 吴春英[1] 罗世能[1] 匡琴芳[1] 冯瑛瑛[1] 谢敏浩[1] 奚月芬[1] 国毓智[1] 

机构地区：[1]江苏省原子医学研究所,无锡214063

出　　处：《同位素》1992年第1期15-19,共5页Journal of Isotopes

摘　　要：^(99)Tc^m-ECD在诊断脑部疾患方面是一种有价值的新型脑灌注显像剂。^(99)Tc^m-ECD通过配体交换方法制备。研究了^(99)Tc^m-GH与ECD之间的配体交换反应时介质的pH值、ECD的浓度、GH的浓度对^(99)Tc^m-GH与ECD进行配体交换反应的影响。结果表明,pH值、ECD的浓度对配体交换反应的影响较显著;并计算了不同pH值的反应速度常数。The complex ^(99)Te^m-ethyl cysteinate dimer (^(99)Tc^m-ECD) which is a valuable brain imaging agent is prepared through the ligand exchange reaction between ^(99)Tc^m-glucoheptonate (GH) and ECD. In order to explore the exchange reaction between the ^(99)Tc^m-GH and N_2S_2 type ligands as a common methodfor the preparation of ^(99)Tc^m-N_2S_2 complexes, the ligand exchange reaction between ^(99)Tc^m-GH and ECD was studies at different pH values, reaction time, ECD and Na-GH concentrations. The exchange ratio was determined by paper chromatography, and the reaction rate constants were calculated at different ECD concentration (pH=6) and different pH values. The results obtained show that the ligand exchange between ^(99)Tc^m-GH and ECD is a second order reaction and the rate constant of the ligand exchange reaction depends on pH values.

关 键 词：葡庚糖酸钠 配体交换 反应速度 ECD 

分 类 号：R817[医药卫生—影像医学与核医学]