念珠状链杆菌在小鼠群中的自然感染和发病特征的观察  

Observation of Natural Infection by Streptobacillusmoniliformis and Streptobacillosis in Mice

作　　者：李红[1] 陈卫兰[1] 蒋观成[1] 

机构地区：[1]中国医学科学院实验动物研究所

出　　处：《中国实验动物学报》1995年第2期80-86,共7页Acta Laboratorium Animalis Scientia Sinica

摘　　要：本文在国内首次报告了念珠状链杆菌在清洁级Ｃ５７ＢＬ／６Ｊ小鼠群中的自然感染，并从临床、病理解剖、病原学及流行病学方面进行了较为详细的观察，在受检的１４例发病动物中，颈部淋巴结肿大、化脓占７１．４％，皮下、肺门淋巴结脓肿分别占５０．０％和２１．４％，多发性关节炎（包括趾、跗关节）占２１．４％，子宫积脓占７．１％，从所有病灶及部分动物的血液、脾、肝、肺、肾均分离到了单一的细菌。该菌在小鼠成功地进行了急性感染实验，受感染动物出现了典型的念珠状链杆菌病的临床及病理特征，即败血症、关节炎、淤血、水肿、紫绀、结膜炎等。所分离的致病菌在病原学上也完全符合念珠状链杆菌的病原学特征。在饲养环境上与发病鼠群有密切关系的其它４个品系小鼠群，即６１５、ＢＡＬＢ／ｃ、ＣＢＡ、ＫＭ，均未波感染，证明在对该菌的易感性方面存在品系差异。e report a natural infection by S. moniliformis in clean C57BL/6Jmice and the clinical. pathological,bacteriological as well as the epizoo-tical characteristicses were observed, which is the first time in China.Among the 14 of examined mice with clinical signs: 71.4% of tha miceshowed the swelling and purulence of the cervical lymph nodes,50.0% and21.4% denionstrated the swelling and purulence of the subcutaneous andhilar lymph nodes of lung, 21.4% showed the polyarthritis including hockand toe joints and 7.l% showed uterine empyema. The same bacterium wasisolated from the lesions of all infected mice and from the blood, spleen,kidney, liver and lung in some of the infected mice. The expsrimentalinfection with the bacterium isolated from the mice was successful and thetypical clinicopathologic signs such as septicemia, arthritis, congestion,edema and cyanosis were observed in SPF mice .The pathogenic characteri-stics of the bacterium was also the same as that of S. moniliformis.However the other 4 mouse strains which closely related to C57BL/6J suchas 615, BALB/c, CBA, KM mice, were not infected by the S.moniliformis.It demonstrated that the susceptibility to S.moniliformis is predominantlyinfluenced by differsnce of strains of the mice.

关 键 词：念珠状链杆菌 小鼠 自然感染 发病特征 

分 类 号：S858.91[农业科学—临床兽医学] Q95-33[农业科学—兽医学]