不同扩张方案下离体皮肤的生物力学特性比较  

COMPARISON OF SKIN BIOMECHANICAL PROPERTIES IN VITRO ACCORDING TO DIFFERENTL EXPANDED METHODS

作　　者：曾衍钧[1] 杨坚[1] 许传青[1] 李瑱[1] 孙广慈[2] 

机构地区：[1]北京工业大学生物力学研究室,北京100022 [2]中国协和医科大学整形外科医院,北京100041

出　　处：《中国生物医学工程学报》2003年第6期559-563,569,共6页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目 ( 10 0 72 0 0 6)

摘　　要：整形外科中 ,人们希望用快速扩张来代替常规扩张 ,因为这样可以大大缩短扩张时间。然而快速扩张后的皮肤特性是否接近于常规扩张 ,这是人们所关切的问题。据此本研究进行了快速和常规扩张的离体皮肤生物力学特性的比较。离体生物力学各参数 ,如强度、应力 应变、应力松弛、蠕变等参数在Instron实验机上的测定和计算结果表明 :扩张后的短时期内 ,扩张皮肤的力学性能相对于其对照组发生较大的偏离 ;但随着维持时间的增加 ,扩张皮肤的力学性能又逐渐接近其对照组。对于同样的维持时间 ,快速扩张和常规扩张对生物力学性质影响区别不大。因此可以得出结论 :快速扩张组的生物力学特性十分接近于常规扩张组 ;延长维持时间可以改变皮肤的生物力学性质 ,使之与对照组接近。因此 ,临床上可以采取缩短扩张期 ,延长维持期的方法来提高疗效。In plastics, people hope that the conventional expansion be replaced by rapid expansion, because expanded period could be shortened greatly. Also people are concered at whether skin properties after rapid expansion approach that after conventional expansion. A comparison of skin biomechanical properties in vitro was carried out. Biomechanical properties in vitro, such as tensile strength, stress-strain, stress-relaxation, and creep were tested by INSTRON material testing machine. Results showed that the biomechanical properties of experimental specimens differed significantly from those of their controls immediately after expansion, however, the difference reduced with time. With the same maintenance period, the biomechanical properties of rapidly expanded skin were similar to those of the conventionally expanded skin. The conclusion is that rapid skin expansion dose not exhibit any deleterious effect when compared with the conventional expansion. Extension at the maintenance period could improve the biomechanical properties of expanded skin. Therefore, rapid expansion with an extended maintenance period is acceptable in clinical practice.

关 键 词：皮肤扩张 维持期 生物力学特性 整形外科 离体皮肤 

分 类 号：R318.01[医药卫生—生物医学工程] R622.1[医药卫生—基础医学]