曲马朵急性戒断反应诱导小鼠大脑皮层μ受体mRNA表达增加  

ACUTE TRAMADOL ABSTINENCE ENHANCES THE EXPRESSION OF MU RECEPTOR mRNA IN CEREBRAL CORTEX OF MICE

作　　者：孙红蕾[1] 梁建辉[1] 王铿 郑继旺[1] 

机构地区：[1]北京大学中国药物依赖性研究所,北京100083

出　　处：《中国药物依赖性杂志》2003年第4期258-261,共4页Chinese Journal of Drug Dependence

摘　　要：目的 :从分子水平探讨曲马朵急性戒断机理及 5 -羟色胺酸、育亨宾对曲马朵急性戒断反应的影响。方法 :利用RT -PCR技术研究小鼠大脑皮层 μ受体mRNA表达的变化。 结果 :曲马朵急性戒断小鼠 μ受体mRNA的表达明显升高 ,增加了 15 3.3% ,而育亨宾和 5 -HTP可抑制曲马朵急性戒断诱导的 μ受体mRNA改变。 结论 :中枢 5 -羟色胺系统和去甲肾上腺素系统对曲马朵急性戒断诱导的小鼠大脑皮层Objective: To study the possible molecular mechanisms underlying acute tramadol abstinence and the effect of 5-hydroxyptrytophan and yohimbine upon acute tramadol withdrawal. Methods: The expression of μ receptor mRNA in cerebral cortex of mice was investigated by RT-PCR. Results: In acute tramadol abstinence mice, the expression of μ receptor mRNA was 153.3% higher than that of control mice, while yohimbine and 5-hydroxyptrytophan inhibited the up-regulation of μ receptor gene expression induced by acute tramadol abstinence. Conclusion: The serotonergic and adrenergic systems in the CNS could regulate the high expression of μ receptor mRNA induced by acute tramadol abstinence in cerebral cortex of mice.

关 键 词：曲马朵 急性戒断反应 小鼠 大脑皮层 μ受体mRNA RT-PCR 中枢5-羟色胺系统 去甲肾上腺素系统 

分 类 号：R971.1[医药卫生—药品] R749.61[医药卫生—药学]