孩尔来福甲型肝炎灭活疫苗免疫儿童后近期抗体动态观察  

Short-term Antibody Dynamics in Children Immunized with Inactivated Domestic Hepatitis A Vaccine

作　　者：任银海 陈江婷[2] 张玉成 马守东[2] 吴文婷 公雪杰 薛伟华 王建红[2] 任一丰 康文学 韩连军 李胜平 刘崇柏[3] 

机构地区：[1]平山县卫生防疫站,河北平山050400 [2]北京科兴生物制品有限公司,北京100085 [3]中国疾病预防控制中心病毒病预防控制所,北京100050

出　　处：《中国计划免疫》2003年第6期340-341,共2页Chinese Journal of Vaccines and Immunization

基　　金："九五"国家医学科技攻关项目 (专题合同号 :96-90 6-0 3 -0 4)

摘　　要：为观察孩尔来福 (Healive)甲型肝炎 (甲肝 )灭活疫苗免疫儿童后的抗体水平及下降规律 ,探讨甲肝灭活疫苗诱导的抗体所提供的持续保护时间 ,对曾接种 5 0 0U/剂 (0、3个月和 0、6个月免疫程序 )Healive甲肝灭活疫苗的113名儿童 ,用酶联免疫吸附试验 (ELISA)分别检测免疫后 12、2 4、36个月的血清抗甲肝病毒抗体。结果显示 :至第 36个月检测时 ,10 0 %的儿童甲肝抗体保持阳性 ;0、3个月程序组 74 1% ,0、6个月程序组 85 4 %的儿童甲肝抗体滴度≥ 2 0 0mIU/ml。With a view to evaluate the antibody titer and antibody descending trend of the domestic inactivated hepatitis A vaccine in immunized children and to find out the duration of protection induced by inactivated hepatitis A vaccine, a total of 113 children once immunized with 500U/dose of domestic inactivated hepatitis A vaccine of 0, 3 and 0, 6 month schedules were observed. Using ELISA method, the serum anti-HAV from all 113 immunized children was detected at 12, 24 and 36 months after vaccination. The results suggested that 100% of the children were anti-HAV positive at 36 months after vaccination. If the antibody >200mIU/ml is considered as positive, the positive rates were 74.1% in 0, 3 month schedule group and 85.4% in 0, 6 month schedule group.

关 键 词：孩尔来福 甲型肝炎 灭活疫苗 免疫 儿童 抗体 动态观察 

分 类 号：R725.126.1[医药卫生—儿科] R186[医药卫生—临床医学]