呼吸机相关性肺损伤的炎症反应机制  

Inflammatory response mechanisms of ventilator-induced lung injury

作　　者：邱海波[1] 陆晓旻[1] 

机构地区：[1]东南大学附属中大医院危重病医学科,南京210009

出　　处：《基础医学与临床》2003年第6期589-594,共6页Basic and Clinical Medicine

摘　　要：机械通气是治疗急性呼吸窘迫综合征的主要手段 ,但呼吸机应用不当也可能加重原有的肺损伤 ,引起呼吸机相关性肺损伤。呼吸机相关性肺损伤本质上是生物伤 ,异常的机械力作用于细胞 ,激活细胞内信号转导通路 ,活化炎性细胞 ,产生大量炎症介质 ,加重炎症反应。探讨呼吸机相关性肺损伤的炎症反应机制 ,阻断机械力作用向细胞内的传导和细胞内信号转导途径的激活 ,减少炎症细胞的激活和炎症介质基因的表达 。Mechanical ventilation is an important therapeutic approach to treat acute respiratory distress syndrome. Inappropriate use of ventilator will aggravate the prime injury of lung and cause ventilator-induced lung injury (VIL-I). So VIL-I is a biotrauma. Abnormal mechanical forces activate the intracellular signal transduction pathways, activate the inflammatory cells, produce lots of inflammatory mediators and aggravate inflammatory responses. The prevention of VIL-I can be implemental by inhibiting extracellular mechanical force conduction and intracellular signal transduction activation, and there by reducing inflammatory cells activation and inflammatory mediators gene expression.

关 键 词：呼吸机相关性肺损伤 炎症反应机制 机械通气 急性呼吸窘迫综合征 丝裂原活化蛋白激酶 

分 类 号：R563.8[医药卫生—呼吸系统]