哮喘豚鼠血浆丙二醛变化及糖皮质激素的干预作用  

Changes of malonic aldehyde in plasma of guinea pigs with asthma and intervention effects of glucocorticoid hormone

作　　者：曹慧玲[1] 李艳[2] 

机构地区：[1]第四军医大学吉林军医学院附属医院呼吸消化内科，吉林吉林132013 [2]第四军医大学吉林军医学院临床检验教研室，吉林吉林132013

出　　处：《第四军医大学吉林军医学院学报（86813X）》2003年第4期191-193,共3页Journal of Jilin Military Medical College Fourth Military Medical University

摘　　要：目的 了解豚鼠哮喘发作时脂质过氧化物(LPO)的变化及糖皮质激素对其影响，以探讨发病机理，并为治疗提供参考依据。方法 制作豚鼠哮喘模型，检测哮喘发作及激素干预后不同时间点(1、24h)LPO代谢产物丙二醛(MDA)、血淋巴细胞(LYM)水平及两者的相关性。结果 MDA含量在哮喘发作后1h上升至(5．36±0．37)nmol／L，24h时为(6．08±0．70)nmol／L，且有时间依存性；激素在哮喘发作早期(1h)对MDA即有抑制作用(4．59±0．68)nmol／L，对后期(24h)影响较小(5．31±0．50)nmol／L；MDA的变化与LYM呈显著正相关(r=0．92)。结论 哮喘发作时氧自由基释放增多，淋巴细胞参与相应反应，糖皮质激素对哮喘早期有较强干预作用。Objective To know the changes of LPO and the influence of glucocorticoid hormone on it in the attack stage of asthma could provided basis for research of its mechanism and its treatment.Methods Guinea pigs were used to prepare models of asthma,and then the level of products of lpometabolism-MDA and LYM and their correlation at different time points(1 hour and 24 hour) were explored in the attack stage and after intervention.Results After the attack of asthma, MDA significantly became(5.36±0.37)for 1 ho...

关 键 词：哮喘 豚鼠 血浆 丙二醛 糖皮质激素 治疗 

分 类 号：R562.25[医药卫生—呼吸系统] R977.1[医药卫生—内科学]