心脏停跳液中主要成分含量测定方法的研究  

Study on analytical methods for determination of main components in car dioplegic infusate

作　　者：陈宝玲[1] 郑英丽[1] 陆直[2] 方丽[1] 顾德良[1] 张正[1] 

机构地区：[1]中国医学科学院阜外心血管病医院药剂科,北京100037 [2]中国医学科学院中国协和医科大学药物研究所,北京100050

出　　处：《中国药学杂志》2003年第12期956-958,共3页Chinese Pharmaceutical Journal

摘　　要：目的　研究心脏停跳液中主要成分含量测定的方法。方法　以容量分析方法中的四苯硼钠法、乙二胺四乙酸二钠法和亚硝酸钠法分别测定停跳液中氯化钾、氯化钙、氯化镁和盐酸普鲁卡因的含量。结果　本方法的平均回收率为 :氯化钾10 0 .3% ,RSD为 0 .2 6 % ;氯化钙 99.91% ,RSD为 0 .5 1% ;氯化镁 99.83% ,RSD为 0 .5 2 % ;盐酸普鲁卡因 10 0 .9% ,RSD为0 .5 4 %。结论　研究表明 ,本方法测定结果准确可靠 ,重现性好 。OBJECTIVE: To establish the necessary analytical methods for the determination of main components in cardioplegic infusate. METHODS: The contents of potassium chloride, calcium chloride, magnesium chloride and procaine chloride in cardioplegic infusate were determined by sodium tetraphenylborion method, disodium edetate method and sodium nitrite method, respectively. RESULTS: The average recoveries of potassium chloride, calcium chloride, magnesium chloride and procaine chloride were 100.3% (RSD=0.26%), 99.91% (RSD=0.51%), 99.83% (RSD=0.52%) and 100.9% (RSD=0.54%), respectively. CONCLUSION: The results indicated that the methods were accurate and reliable with good reproducibilities. This study provided a quality control method for cardioplegic infusate.

关 键 词：心脏停跳液 含量 测定 容量分析方法 四苯硼钠法 亚硝酸钠法 

分 类 号：R927.2[医药卫生—药学]