CGEONA对荷LA-795肺腺癌小鼠和正常小鼠放射敏感性的影响(英文)  

Effect of CGEONA on radiosensitivity of LA-795 pulmonary adenocarcinoma-bearing mice and normal mice

作　　者：周则卫[1] 胡璧[1] 沈瑜[2] 王争[2] 张荷清[1] 

机构地区：[1]中国医学科学院中国协和医科大学放射医学研究所 [2]中国医学科学院中国协和医科大学肿瘤研究所,北京100021

出　　处：《辐射研究与辐射工艺学报》2003年第4期256-259,共4页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金(39370226)资助

摘　　要：为了寻找低毒有效的放射增敏剂,观察CGEONA(羧基-苯乙烯基锗倍半氧化物钠盐)对荷瘤小鼠和正常小鼠放射敏感性的影响。放射增敏实验用T-739小鼠,肿瘤模型LA-795肺腺癌,采用肿瘤生长延迟法评价效果;放射防护实验用昆明种小鼠,观察30d存活率和对造血系统的影响。结果表明,CGEONA药物浓度为1/10 LD50时平均放射增敏比为1.4。放射防护实验给药组与对照组相比,存活率以及造血系统指标无显著差异(p>0.05)。表明CGEONA是新型低毒有效放射增敏剂,对照射的正常动物无放射增敏作用,值得进一步研究。In search for less toxic and more effective radio-sensitizer, the effects of CGEONA (Carboxy-β-phenyl-vinyl-germanium sesquioxide sodium salt)on radio-sensitivity of tumor-bearing mice and normal mice were investigated. Radiosensitizing experiment was performed using T-739 mice. The tumor model was LA-795 pulmonary adenocarcinoma, and the effect was assessed using tumor regrowth delay. Radioprotection experiments were performed using Kunming mice. The 30-day survival rate and effects on hemopoietic system were observed. It was shown that the average sensitization enhancement ratio (SER) of CGEONA was 1.4 with 1/10 LD50drug dosage. The radioprotection experiments showed no significant differece between treated mice and control mice for survival rate and hemopoietic system. Thus, CGEONA shows great potential as a new type of radiosensitizer with less toxicity and more effectiveness. It has no radiosensitizing effect on normal mice and is worthy of further studies.

关 键 词：CGEONA 放射增敏剂 荷瘤小鼠 放射增敏实验 肺腺癌 肿瘤生长延迟法 放射防护实验 平均放射增敏比 

分 类 号：R979.19[医药卫生—药品]