eIF-5A与hypusine  

eIF-5A and hypusine

作　　者：靳宝锋[1] 何昆[1] 张学敏[1] 

机构地区：[1]军事医学科学院基础医学研究所,北京100850

出　　处：《军事医学科学院院刊》2003年第6期463-466,共4页Bulletin of the Academy of Military Medical Sciences

基　　金：国家高技术研究发展计划"863"资助项目( 2 0 0 1AA2 3 3 0 41)

摘　　要：翻译起始因子eIF_5A在真核细胞内普遍存在 ,是目前为止惟一发现含独特氨基酸hypusine残基的蛋白。hypusine是eIF_5A前体的特定赖氨酸残基 (第 5 0位 )经亚精胺依赖性的翻译后修饰形成的 ,每一成熟的eIF_5A仅含一个hypusine残基 ,eIF_5A的hypusine修饰是其发挥功能、细胞存活和增殖所必需的。本文对eIF_5A的研究历史、现状和hypusine功能的近期进展进行了概述 ,并进一步分析了eIF_5A的可能功能及hypusine修饰过程作为药物靶标诱导细胞凋亡的应用前景。Eukaryotic translation initiation factor 5A (eIF-5A) is the only cell protein that contains the unusual basic amino acid hypusine. Hypusine formation on eIF-5A is essential for cell survival and proliferation, but the precise functions of eIF-5A and hypusine formation remain elusive. Agents that reduce cell hypusine levels inhibit the growth of mammalian cells. In this review the novel insights on the biochemical and molecular events leading to hypusine formation and its involvement in the cellular processes are summarized.

关 键 词：EIF-5A HYPUSINE 蛋白质合成 细胞凋亡 

分 类 号：R341[医药卫生—基础医学]