益母草对小鼠雄性生殖细胞遗传损伤的影响  

Effect of Leonurus Heterophullus on the Genetic Damage in Genital Cells of Male Mice

作　　者：朱玉琢[1] 庞慧民[1] 邢沈阳[2] 高久春[3] 胥耘荆 

机构地区：[1]吉林大学基础医学院医学遗传学教研室,吉林长春130021 [2]吉林大学护理学院生物学教研室 [3]吉林大学基础医学院细胞生物学教研室 [4]吉林省高等法院

出　　处：《吉林大学学报（医学版）》2003年第6期756-758,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省科研发展计划资助课题 (2 0 0 1 0 5 2 9)

摘　　要：目的 :观察中草药益母草对醋酸铅引起的小鼠雄性生殖细胞遗传损伤的影响。方法 :采用小鼠精原细胞姐妹染色单体交换实验。结果 :益母草本身不能诱发小鼠精原细胞姐妹染色单体交换 ,但在与醋酸铅一同给药时 ,可使醋酸铅所诱发的小鼠精原细胞姐妹染色单体交换频率明显降低。结论 :益母草对小鼠雄性生殖细胞遗传物质具有保护作用 ,即抗诱变作用。Objective:To observe the effect of leonurus heterophullus on genetic damage induced by Pb(CH 3COO) 2 in genital cells of male mice. Methods:The sister chromatid exchange (SCE) test in mice spermatogonia was used in the study. Results:Leonurus heterophullus could not induce SCE in mice spermatogonia,but the frequencies of SCE induced by Pb(CH 3COO) 2 in mice spermatogonia were reduced significantly if leonurus heterophullus and Pb(CH 3COO) 2 were given simultaneously. Conclusion:Leonurus heterophullus shows a protective effect, namely antimutagenesis,on genetic materials in male genital cells.

关 键 词：益母草 抗诱变药 醋酸铅 精原细胞 姐妹染色单体交换 诱变力试验 雄性生殖细胞遗传损伤 

分 类 号：R285[医药卫生—中药学] R321.1[医药卫生—中医学]