人工肝支持系统治疗对重型肝炎患者血清TNF-α、IL-6水平的影响  

Effects of Artificial Liver Support System on Serum Levels of TNF-α,IL-6 in Patients with Severe Hepatitis

作　　者：徐龙[1] 何金秋[1] 邓见廷[1] 刘燕[1] 齐青松[1] 祁红霞[1] 

机构地区：[1]南昌市第九医院,江西南昌330002

出　　处：《江西医学院学报》2003年第6期77-79,共3页Acta Academiae Medicinae Jiangxi

摘　　要：目的　了解重型肝炎患者经人工肝支持系统 (ALSS)治疗前后外周血中TNF α、IL 6变化。方法　采用ELISA方法检测 4 3例重型肝炎患者的上述指标。结果患者血清TNF α、IL 6治疗前分别为 ( 70 .32± 2 0 .31) pg/ml、( 6 3.0 2± 15 .19) pg/ml,较正常值均有明显升高 (P <0 .0 0 1) ;治疗后分别为 ( 4 1.8± 18.4 2 ) pg/ml、( 35 .37±13.0 8) pg/ml,与治疗前比较明显降低 (P <0 .0 0 1)。治疗后患者存活率为 6 7.5 %。 结论　ALSS治疗后能降低外周血TNF α、IL 6含量 ,从而减轻重型肝炎时免疫反应对肝细胞的损伤 ,提高重型肝炎的存活率。Objective To study the changes of TNF α,IL 6 in patients with severe hepatitis before and after treatment with artificial liver support system(ALSS).Methods TNF α and IL 6 were measured by using ELISA.Results Patients had abnormal TNF α(70.32±20.31 pg/ml),IL 6(63.02±15.19 pg/ml)before treatment when compared to those (41.8±18.42 pg/ml),(35.37±13.08 pg/ml)in the controls. Only when the serum TNF α,IL 6 decreased at least by 30% would the chances of their survival be increased.Conclusion ALSS can decrease the level of TNF α,IL 6 attenuating immune injury of hepatocyte in severe hepatitis patients and increasing the chances of their survival.

关 键 词：重型肝炎 人工肝支持系统 TNF-Α IL-6 

分 类 号：R512.6[医药卫生—内科学]