益气升阳、活血安神中药复方对急性耐力运动后大鼠不同脑区单胺类神经递质的影响  

Influence of Chinese Herbal Preparations on Monoamine Neurotransmitters and Its Metabolites in Different Brain Region in Rat after Single Bout of Prolonged Exercise

作　　者：宋亚军[1] 孙勤枢[2] 王宁[2] 王鲁克[1] 梁玉记[3] 谢敏豪[4] 

机构地区：[1]山东济宁师范专科学校体育系,济宁272000 [2]山东济宁医学院化学教研室 [3]山东济宁医学院药理教研室 [4]北京体育大学运动人体科学学院

出　　处：《中国运动医学杂志》2004年第1期38-41,共4页Chinese Journal of Sports Medicine

基　　金：山东省教育厅科技计划项目 (NO :J0 1K5 4 )部分内容

摘　　要：目的 :为运用中医药推迟或消除运动性中枢疲劳提供依据。方法 :检测大鼠端脑、间脑和脑干 5 -HT、DA和 5 -HT/DA等指标 ,探讨补充中药对大鼠急性耐力运动后及恢复期单胺类神经递质的影响。结果 :①补充益气升阳、活血安神类复方中药可使大鼠各脑区 5 -HT和DA的基础水平降低。②补充中药可使大鼠各脑区 5 -HT对急性耐力运动反应的敏感性降低 ,提示中药对推迟运动性中枢疲劳可能有一定的作用 ,但可能会对大鼠运动后的恢复质量产生负面影响 ,使运动鼠恢复期疲劳加重。③补充中药后 ,大鼠急性耐力运动后即刻各脑区DA含量变化与未服药组相比呈相反趋势 ,运动后 2 0小时亦表现出不同的变化趋势 ,这可能与中药对脑内DA的合成与分解代谢的调节有关。④中药对大鼠各脑区 5s This study was designed to observe the influence of Chinese herbal preparations on 5-HT and DA and their ratio in cortex and diencephalon and brain stem of the rat immediately after single bout of prolonged exercise and 20 min after exercise. Results: ①The Chinese herbal preparations could reduce the base line of the 5-HT and DA in three brain region in rat.②The supplement of Chinese herbal preparations could reduce the sensitivity of the reaction of the prolonged exercise, indicating that Chinese herbal preparations could postpone central fatigue in some extend, whereas the negative influence on recovery quality should be considered. ③The tendency of the change of DA in rat with administration of Chinese herbal preparations was totally inversed in comparison to those without administration of Chinese herbal preparations, as well as the tendency 20 min after exercise. ④ The supplement of Chinese herbal preparations caused the change of 5-HT/DA in different locations of brain in different patterns.

关 键 词：益气升阳 活血安神 中药复方 急性耐力运动 大鼠 单胺类神经递质 运动性中枢疲劳 

分 类 号：R87[医药卫生—运动医学]