充血性心力衰竭患者血浆瘦素水平的变化及其临床意义  

THE CHANGE OF PLASMA LEPTIN LEVELS AND ITS CLINICAL SIGNIFICANCE IN PATIENTS WITH CONGESTIVE HEART FAILURE

作　　者：张金国[1] 杨娜[1] 王学忠[1] 宋光耀[1] 王智[1] 王进华[1] 王小平[1] 

机构地区：[1]河北省人民医院心脏中心

出　　处：《济宁医学院学报》2003年第4期4-6,共3页Journal of Jining Medical University

摘　　要：目的　探讨充血性心力衰竭 (CHF)患者血浆瘦素 (Leptin)水平的变化及其临床意义。 方法　应用ELISA法测定 4 5例男性CHF患者 (CHF组 )和 30例男性健康查体者 (对照组 )血浆Leptin水平 ,同时分别测量体重指数 (BMI)、腰围 /臀围比 (WHR)及血压等 ,采用改良Simpson法测定CHF组患者左室射血分数 (LVEF)。比较CHF组与对照组及CHF组不同病因亚组血浆Leptin水平变化 ,并将NYHA心功能分级与Leptin水平进行相关分析。 结果　CHF组患者血浆Leptin水平明显高于对照组 (P <0 0 0 1 ) ,且随NYHA心功能分级的增高 ,血浆Leptin水平呈升高趋势 ,两者显著相关 (rs=0 875 ,P <0 0 0 1 ) ;CHF组不同病因亚组血浆Leptin水平无显著性差异 (P >0 0 5 )。 结论　CHF患者血浆Leptin水平升高 ,并与心衰的严重程度相关 ;Objective To determine the change of plasma leptin levels and its clinical significance in patients with congestive heart failure (CHF).Methods The levels of plasma leptin in 45 male patients with CHF and 30 healthy males were detected by ELISA,and body mass index (BMI),waist/hip ratio (WHR) and blood pressure were measured respectively.Left ventricular ejection fraction (LVEF) in the CHF group was measured by improved Simpson method.Plasma leptin levels in the CHF group,the control group and the CHF sub-group with different etiology were compared,and then spearman rank correlation analysis was applied for the association between NYHA cardiac function and plasma leptin levels.Results The plasma leptin levels in the CHF group were higher compared with the control group (P<0.001).There was an increased trend of plasma leptin levels in the CHF group with the increase of NYHA class (r s=0.875,P<0.001).According to different etiology,there was no significant difference of plasma leptin levels in the CHF group (P>0 05).Conclusion Plasma leptin levels were raised and correlated with disease severity in patients with CHF.Hyperleptinaemia may play a role in the pathophysiology of CHF such as catabolic process and activation of the neurohormon.

关 键 词：充血性心力衰竭 血浆瘦素 ELISA法 测定 

分 类 号：R541.61[医药卫生—心血管疾病]