米非司酮(Ru486)治疗子宫内膜异位症的临床分析  

Clinical study on Mifepristone in Treating Endometriosis

作　　者：李萍[1] 张爱武[1] 殷蕙蓉[1] 史承明[1] 

机构地区：[1]南京医科大学附属南京第一医院,210006

出　　处：《齐齐哈尔医学院学报》2003年第12期1335-1336,共2页Journal of Qiqihar Medical University

摘　　要：目的　探讨Ru4 86治疗子宫内膜异位症的疗效。方法　 6 2例子宫内膜异位症患者口服Ru4 86 12 .5～ 2 5mg/d ,连续 3～ 6个月。观察治疗前后症状、体征及比较用药前后血清性激素水平。 结果　在治疗期间所有患者均闭经 ,与治疗前比较 ,总主观症状评分于治疗 3个月后下降了 80 .2 % ,6个月后下降了 91.8% (P <0 .0 1) ;用药 3个月血孕激素水平比用药前显著降低 ,黄体生成素升高 ,雌激素水平降至卵泡中期水平 ,促卵泡激素水平均无变化。停止治疗后于 4～ 6周恢复月经。不良反应为潮热。结论　Ru4 86治疗子宫内膜异位症效果良好 ,副作用小 。Objective To explore the efficacy of mifepristone in treating endometriosis. Methods 62 patients with endometriosis were treated by oral mifepristone 12.5 mg～25 mg/d, once a day, for 3～6 months. The comparison of signs, symptoms and the level of serum norm one before and after treatment was made. Results During treatment, menstruation of all the patients stopped. As compared with that before treatment, total subjective symptom scores decreased by 80.2% after 3 months treatment and decreased by 91.8% after 6 months treatment (P<0.01). 3 months later after using mifepristone, serum level of progestogen significantly decreased as compared with that before treatment. Estrogen level reduced to be the same as in middle follicle phase, but luteinizing norm one and menotropin had no change. 4～6 weeks after treatment was stopped, menstruation restarted. The main side effects were hot flush. Conclusions Mifepristone is effective and safe in treating endometriosis, with little side effects, which is another conventional way to treat endometriosis.

关 键 词：米非司酮 子宫内膜异位症 临床疗效 血清性激素 黄体生成素 不良反应 

分 类 号：R977.1[医药卫生—药品] R711.71[医药卫生—药学]