促甲状腺素释放激素对小鼠免疫功能的影响  

EFFECT OF THYROTROPIN RELEASING HORMONE ON IMMUNE ACTIVITY OF MICE

作　　者：曲卫敏[1] 吴敏毓[1] 

机构地区：[1]皖南医学院微生物学教研室

出　　处：《皖南医学院学报》1992年第1期5-7,共3页Journal of Wannan Medical College

摘　　要：本文观察促甲状腺素释放激素(TRH)对正常小鼠脾脏 T.B 细胞和免疫抑制小鼠免疫器官重量的影响.发现 TRH0.01～7.29nmol/L 剂量可提高小鼠脾细胞免疫特异性花结形成细胞数,而对产生抗羊红细胞抗体的功能无影响.0.0011～2.43nmol/LTRH对 ConA 诱导的 T 细胞转化有显著增强作用.TRH(0.2μg/只)能显著提高氢化可的松抑制小鼠的脾指数,而对正常小鼠脾指数影响不明显.提示 TRH 免疫调节作用存在明显的剂量效应关系,并与机体的免疫状态有关.The influence of TRH on function of spleen T,B lymphocytes in normal mice and on immune organ weight in immunodepressive mice was studied.It was found that TRH at concentra- tions from 0.01 to 7.29nmol / L could increase S-RFC of mouse splenic cell in vitro,But not QHS. TRH at concentrations ranging from 0.0011to 2.43 nmol/L could significantly enhance ~3H-TdR uptake of T lymphocyte induced by ConA.The dose of TRH(0.2ug/mouse) i.p could significantly increase splenic index which was inhibited by HC.The results suggest that TRH may have immunoregulation.

关 键 词：免疫功能 促甲状腺素 释放激素 

分 类 号：R392.12[医药卫生—免疫学]