急性受热及热适应对机体免疫系统的影响  

The Effects of Heat Exposure and Heat Acclimatization on Immune System

作　　者：吴扬[1] 邬堂春[1] 张伟[1] 贺涵贞[1] 张国高[1] 

机构地区：[1]同济医科大学职业医学研究所

出　　处：《劳动医学》1995年第1期1-3,共3页

基　　金：卫生部基金

摘　　要：雄性ＳＤ大鼠随机分为５组：２５℃对照组，３７℃每天２ｈ共７天热适应组，４２℃分别受热３０ｍｉｎ、６０ｍｉｎ，９０ｍｉｎ的３个热处理组。检测全血淋巴细胞转化率、α－醋酸萘酯酶活性、腹腔巨噬细胞活性和吞噬功能。结果显示：７天热适应组与受热３０ｍｉｎ组即明显降低，随受热时间延长（超过３０ｍｉｎ），巨噬细胞吞噬功能显著降低，不能形成吞噬峰。７天热适应组与受热３０ｍｉｎ组用ＰＨＡ刺激全血淋巴细胞转化的刺激指数比对照组稍高，但差异不明显（Ｐ＞０．０５），而６０ｍｉｎ和９０ｍｉｎ受热却使该指数显著下降（Ｐ分别为０．００３１和０．００６３）。α－醋酸萘酯酶除热适应组降低外，其余各组无明显变化。结果提示，急性受热时机体免疫系统功能有受抑制倾向。Thirty male SD rats were divided into 5 groups,each group consisted of 6 rate, and was exposed to following condition: (1) 25℃ as a control group, (2) 37℃,2h heat exposure per each day for 7 days,(3)42℃ acute exposure for 30 min,(4)42℃ acute exposure for 60 min, and (5)42℃ acute exposure for 90 min. Biological activity of interleukin-1,macrophage chemiluminescence,lymphocyte proliferation and α-acetic-naphthylesterase were examined as indicators of the effects of this study.The results showed that the phagocytosis function of macrophage decreased significantly in heat acclimatization and heat-treated groups, and the decrease was heat exposure time dependent. The stimulation index of lymphocyte proliferation with 3H-thymidine incorporation was slightly higher in heat acclimatization and heat treatment for 30 min group than that in control (p>0.05), however,that in heat treatment for 60 and 90 min wassignificanfly higher than that in control (p<0.01).α-Acatic-naphthylesterase decreasd heat acclimatization and had no ch ange in other groupe compared with control.These results indicated that the function of immune system might be suppressed in acute heat exposure.

关 键 词：急性受热 热适应 免疫系统 大鼠 淋巴细胞转化 α-醋酸萘酯酶 腹腔巨噬细胞 

分 类 号：R594.1[医药卫生—内科学]