Spermicidal Effect of Propranolol and Its Isomers onHuman Sperm in vitro  

作　　者：陆仁康 袁德祥 

机构地区：[1]InstituteofReproductiveMedicine,WannanMedicalCollege,Wuhu,Anhui,241001,China [2]TianjinMunicipalResearchInstituteforFamilyPlanning,Tianjin,300191,China

出　　处：《Journal of Reproduction and Contraception》1995年第1期19-25,共7页生殖与避孕（英文版）

摘　　要：Fourly semen samples were collected from healthy volunteers by masturbation. The samples were then divided into four groups according to the quality and quantity of the sperm. The propranolol (D,L-P) and its isomers including the Dextko-propranolol (D-P) and LevoAnpropranolol (L-P) solution of various concentrations were tested. SPermicidal e/fect at various intervals was observed by microscopy, and then compared to the Nonoxynol (NP-9) as a reference spermicide.The results showed that the mean values of lowest effective spermicidal concentration of D,L-P, D-P and L-P within twenty seconds were 1.00±0.63,1.10±0.62 and 0.91 ±0.54 (mg/ml) respectively, there was no signijicant difference among them (P>0.05), but they were signilicantly different from that of NP-9 (P<0.001). It is well known that the D- P has no significant beta- adrenoceptor blocking activity, so the D-P might be a new promising vaginal contraceptive drug.Fourly semen samples were collected from healthy volunteers by masturbation. The samples were then divided into four groups according to the quality and quantity of the sperm. The propranolol (D,L-P) and its isomers including the Dextko-propranolol (D-P) and LevoAnpropranolol (L-P) solution of various concentrations were tested. SPermicidal e/fect at various intervals was observed by microscopy, and then compared to the Nonoxynol (NP-9) as a reference spermicide.The results showed that the mean values of lowest effective spermicidal concentration of D,L-P, D-P and L-P within twenty seconds were 1.00±0.63,1.10±0.62 and 0.91 ±0.54 (mg/ml) respectively, there was no signijicant difference among them (P>0.05), but they were signilicantly different from that of NP-9 (P<0.001). It is well known that the D- P has no significant beta- adrenoceptor blocking activity, so the D-P might be a new promising vaginal contraceptive drug.

关 键 词：PROPRANOLOL ISOMER SPERMICIDE CONTRACEPTIVE 

分 类 号：R965[医药卫生—药理学] R972[医药卫生—药学]