急性心肌梗死患者住院期间生存和死亡及再灌注与血清肌钙蛋白Ⅰ浓度的关系  

THE PROGNOSIS SIGNIFICANCE OF SERUM CARDIAC TROPONIN I CONCENTRATION ON PATIENTS WITH ACUTE MYOCARDIAL INFACTION DURING HOSPITALIZATION

作　　者：张铸[1] 叶萍[1] 陈叶芳[1] 陈阳[1] 张寄南[2] 

机构地区：[1]江苏省靖江市人民医院心内科,214500 [2]江苏省人民医院心内科

出　　处：《中国心血管病研究》2003年第3期175-177,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的通过比较急性心肌梗死(AMI)患者胸痛发作后各时间段血清肌钙蛋白I(cTnI)浓度与住院期间存活和死亡关系,探讨cTnI浓度在急性心肌梗死中的临床价值。方法对172例AMI患者在不同时间段进行血清cTnI浓度测定,比较住院期间存活组与死亡组血清cTnI浓度的变化,以及冠状动脉(冠脉)再灌注对其的影响。结果 AMI患者住院期间死亡患者的血清cTnI浓度明显高于存活患者;住院期间存活患者中胸病发作后18h内,再通者明显高于未通者;住院期间死亡患者中冠脉再通与未通者血清cTnI浓度差异无显著性。结论 血清cTnI浓度与ANI患者的预后有关,死亡患者在胸痛发作后各时间段的血清cTnI浓度均明显升高;存活患者冠脉再通峰浓度增高,峰值提前;死亡患者再灌注与否对血清cTnI浓度无明显影响。Objective To assess the clinical value of serum cardiac troponin I on patients with acute myocardial infarction(AMI) and compared the concentration of serum cardiac troponin I (cTn I ) with fatality rates during hospitalization and reperfusion. Methods Blood samples of 172 cases with AMI were collected at specific time points. Concentration of serum cardiac troponin I were compared among following groups: survival, dead, reperfusion, non - reperfusion. Results The serum cTn I concentrations of dead during hospitalization were significantly higher than that of survival at all time points after chest pain onset. In the survival group, The serum cTn I concentrations of patients with reperfusion were significantly higher than that with non- reperfusion during the first 18 hours after onset of chest pain. In the dead group, there was no significantly difference between the serum cTn I concentration of reperfusion and non- reperfusion patients. Conclusion Serum cTn I concentration was associated with the prognosis of AMI patients during hospitalization. The serum cTn I concentrations were significantly higher than that in dead. Peak serum cTn I concentrations of reperfusion survival were higher and be put forward.

关 键 词：急性心肌梗死 住院期 血清肌钙蛋白I AMI CTNI 

分 类 号：R542.22[医药卫生—心血管疾病]