慢性乙型肝炎肝纤维化程度的模糊聚类分析  

Fuzzy cluster analysis of blood fibrosis markers of chronic hepatitis B

作　　者：刘霞[1] 刘锐宽[2] 赵恭华[1] 王泰龄[1] 

机构地区：[1]中日友好医院病理科,北京100029 [2]辽宁工程技术大学基础科学部,辽宁阜新123000

出　　处：《辽宁工程技术大学学报（自然科学版）》2003年第6期853-854,共2页Journal of Liaoning Technical University (Natural Science)

基　　金：北京中日友好医院科研基金资助项目(200329)

摘　　要：在中日友好医院临床及病理确诊的45例慢性乙型肝炎病例中,随机抽取9例通过血清肝纤维化指标进行基于等价矩阵的模糊聚类,判定肝纤维化程度。并按2000年全国传染病防治方案制定的慢性乙型肝炎病理诊断标准进行纤维化分期。模糊聚类结果与肝穿病理纤维化程度基本一致。依此建立慢性乙型肝炎纤维化预报模型,采用3例待预报样本进行验证,证实本模型利用无损伤的方法对判定肝纤维化程度具有一定的实用性。Nine cases of chronic hepatitis B were detected in blood fibrosis markers (IV ,PIIIP, HA, LN ),and liver biopsy. The fibrosis degree was divided into four stages on pathology. The fuzzy cluster method was applied according to blood fibrosis markers. The model of determination liver fibrosis was built. Another 3 cases of chronic hepatitis B were predicted about the liver fibrosis using this model. The results were in concordance with pathologic fibrosis stage through liver biopsy. The conclusion is that fuzzy cluster method is a useful tool for evaluating the fibrosis of chronic hepatitis B.

关 键 词：慢性乙型肝炎 肝纤维化 模糊聚类分析 病理 

分 类 号：R512.62[医药卫生—内科学]