芪月降脂片制粒工艺的优化  

Optimization of preparation technique for the Qiyuejiangzhi tablets

作　　者：郭建鹏[1] 金在久[1] 崔京浩[1] 全姬善[1] 关志宇[1] 李水林[2] 李凤龙[1] 

机构地区：[1]延边大学药学院,吉林延吉133000 [2]延边大学,吉林延吉133002

出　　处：《延边大学医学学报》2003年第4期243-245,共3页Journal of Medical Science Yanbian University

摘　　要：[目的 ]优化芪月降脂片制剂成型工艺中的制粒工艺 .[方法 ]以最佳制剂处方为基础 ,采用正交设计和多指标综合评分法对高速搅拌湿法制粒工艺进行优化 .[结果 ]最佳制剂工艺为切桨用快速档、搅桨用慢速档 ,搅拌时间为 4min ,润湿剂加入量为 42mL .[结论 ]该工艺合理 。OBJECTIVETo optimize the important step -o f granulation technique for modeling of the Qiyuejiangzhi tablets. METH ODSThe technique of high speed wet granulation was optimized by using orthogonal design and multi-index compositive score method to taking the be st f ormulation as the basis. RESULTS The best preparation tech niqu e was that the cutting paddle put on speediness level and the impeller on slowne ss level, and the churning time was for 4min, and 42mL of the wetting agent was added. CONCLUSION This technique is reasonable and the molding of the tablets prepared by this technique is good.

关 键 词：片剂 制剂 成型工艺 正交设计 芪月降脂片 

分 类 号：TQ461[化学工程—制药化工]